Acute changes in sputum IL-10 following underground exposure to diesel exhaust.

Acute changes in sputum IL-10 following underground exposure to diesel exhaust. Research Abstract Details 

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Acute changes in sputum IL-10 following underground exposure to diesel exhaust. Abstract Text:

Jefferey L Burgess,Joy E Fleming,Emmanuel M Mulenga,Arun Josyula,Tracy A Hysong,Philip J Joggerst,Margaret Kurzius-Spencer,Hugh B Miller,

INTRODUCTION: Although exposure to diesel exhaust has been linked with adverse health effects, little is known about the acute effects of exposure in the underground workplace. METHODS: Cross-shift spirometry and sputum induction were completed on twelve subjects associated with comminuted rock removal (mucking) operations in an underground copper mine using diesel powered and pneumatic equipment on separate days, and sputum collected on a baseline non-exposure day as well. RESULTS: For diesel operations, elemental carbon exposure averaged 538 +/- 512 microg/m(3) during the 1-2 hour operations. Sputum interleukin-10 decreased with diesel exhaust using one ELISA assay (3.69 v. 2.32 pg/ml, p = 0.015), but increased when measured with a different ELISA kit (0.18 v. 0.59 pg/ml, p = 0.019), consistent with an overall decline in IL-10 protein concentration but an increase in the biologically active form. Sputum interleukin-6 decreased with exposure to diesel exhaust, although this change lost statistical significance when restricted to non-smokers. There were no significant changes in spirometry, interleukins 1beta, 4, and 8, tumor necrosis factor alpha or 8-hydroxy-2'-deoxyguanosine. CONCLUSION: High levels of diesel exhaust can result in rapid changes in sputum IL-10, suggesting possible protein modification.

Acute changes in sputum IL-10 following underground exposure to diesel exhaust. Publishing Authors By Initials

JL Burgess,JE Fleming,EM Mulenga,A Josyula,TA Hysong,PJ Joggerst,M Kurzius-Spencer,HB Miller,

For similar complex mixtures: vehicle emissions research abstracts see: complex mixtures: vehicle emissions research

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Acute changes in sputum IL-10 following underground exposure to diesel exhaust. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical toxicology (Philadelphia, Pa.)

VOLUME: 45

Page Numbers: 255-60

Journal Abbreviation:

ISSN: 1556-3650

DAY: 3

MONTH: 12

YEAR: 2007

Acute changes in sputum IL-10 following underground exposure to diesel exhaust. Information

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LANGUAGE: eng

NlmUniqueID: 101241654

Acute changes in sputum IL-10 following underground exposure to diesel exhaust. Keywords Mesh Terms:

KEYWORDS: Vehicle Emissions

MESH TERMS: toxicity

Chemical & Substance for Abstract: Acute changes in sputum IL-10 following underground exposure to diesel exhaust. Information

Substance Name: Interleukin-10

Registry Number: 130068-27-8

Grant and Affiliation Information for Acute changes in sputum IL-10 following underground exposure to diesel exhaust.

AFFILIATION: University of Arizona, Tucson, Arizona 85724-5210, USA. jburgess@u.arizona.edu

Country: United States

AGENCY: United States PHS

GRANT: T42/CCT918726

ACRONYM: ES

MEDLINETA: Clin Toxicol (Phila)

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