Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin.

Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Abstract Text:

Lacy A Holowatz,Caitlin S Thompson,W Larry Kenney,

Full expression of reflex cutaneous vasodilation (VD) is dependent on nitric oxide (NO) and is attenuated in older humans. NO may be decreased by an age-related increase in reactive oxygen species or a decrease in L-arginine availability via upregulated arginase. The purpose of this study was to determine the effect of acute antioxidant supplementation alone and combined with arginase inhibition on reflex VD in aged skin. Eleven young (Y; 22 +/- 1 yr) and 10 older (O; 68 +/- 1 yr) human subjects were instrumented with four intradermal microdialysis (MD) fibers. MD sites were control (Co), NO synthase inhibited (NOS-I), L-ascorbate supplemented (Asc), and Asc + arginase-inhibited (Asc + A-I). After baseline measurements, subjects underwent whole body heating to increase oral temperature (T(or)) by 0.8 degrees C. Red blood cell flux was measured by using laser-Doppler flowmetry, and cutaneous vascular conductance (CVC) was calculated (CVC = flux/mean arterial pressure) and normalized to maximal (CVC(max)). VD during heating was attenuated in O (Y: 37 +/- 3 vs. O: 28 +/- 3% CVC(max); P < 0.05). NOS-I decreased VD in both groups compared with Co (Y: 20 +/- 4; O: 15 +/- 2% CVC(max); P < 0.05 vs. Co within group). Asc and Asc + A-I increased VD beyond Co in O (Asc: 35 +/- 4% CVC(max); Asc + A-I: 41 +/- 3% CVC(max); P < 0.001) but not in Y (Asc: 36 +/- 3% CVC(max); Asc + A-I: 40 +/- 5% CVC(max); P > 0.05). Combined Asc + A-I resulted in a greater increase in VD than Asc alone in O (P = 0.001). Acute Asc supplementation increased reflex VD in aged skin. Asc combined with arginase inhibition resulted in a further increase in VD above Asc alone, effectively restoring CVC to the level of young subjects.

Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Publishing Authors By Initials

LA Holowatz,CS Thompson,WL Kenney,

For similar vasodilation research abstracts see: vasodilation research

PUBMED ID PMID:

MEDLINE DATE:

Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Heart and circulat

VOLUME: 291

Page Numbers: H2965-70

Journal Abbreviation: Am. J. Physiol. Heart Circ. Ph

ISSN: 0363-6135

DAY: 11

MONTH: 08

YEAR: 2006

Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901228

Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Keywords Mesh Terms:

KEYWORDS: Vasodilation

MESH TERMS: drug effects

Chemical & Substance for Abstract: Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Information

Substance Name: Arginase

Registry Number: EC 3.5.3.1

Grant and Affiliation Information for Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin.

AFFILIATION: Noll Laboratory, Pennsylvania State University, University Park, PA 16802, USA. lma191@psu.edu

Country: United States

AGENCY: United States NIA

GRANT: R01-AG-07004-15

ACRONYM: AG

MEDLINETA: Am J Physiol Heart Circ Physio

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin Related Publications

• 24-Hour cooled storage of equine embryos.
• A comparison between cervical dimensions of pregnant and nonpregnant Santa Gertrudis and Bos taurus cows.
• Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin.
• Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas.
• Aspiration of oocytes from mature and immature preovulatory follicles in the mare.
• Characterizations of distinct amyloidogenic conformations of the Abeta (1-40) and (1-42) peptides.
• Comparison between two techniques for endometrial swab culture and between biopsy and culture in barren mares.
• Comparison of pregnancy rates achieved with frozen semen using two packaging methods.
• Comparison of two techniques for obtaining endometrial bacteriologic cultures in the mare.
• Consumer informatics in primary care.
• Dehydration impairs vigilance-related attention in male basketball players.
• Effect of vitamin E on the production of collagen, DNA and fibronectin in keratocytes in vitro.
• Effects of cooling rate and storage temperature on equine spermatozoal motility parameters.
• Effects of semen fractionation and dilution ratio on equine spermatozoal motility parameters.
• Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9.
• Evaluation of androgenized mares as an estrus detection aid.
• Impaired defense of core temperature in aged humans during mild cold stress.
• Investigation of the representativeness of a single endometrial sample and the use of trichrome staining to aid in the detection of endometrial fibrosis in the mare.
• Methods of analysis and physiological relevance of rhythms in sympathetic nerve discharge.
• Periparturient events in ovariectomized embryo transfer recipient mares.
• Prediction models for core temperature during heat stress vary with exercise intensity: 2365: board #44 june 1 2:00 PM -3:30 PM.
• Progressive dehydration causes a progressive decline in basketball skill performance.
• Responses to mild cold stress are predicted by different individual characteristics in young and older subjects.
• Surgical repair of the lacerated cervix in the mare.
• Two percent dehydration impairs and six percent carbohydrate drink improves boys basketball skills.
• Up-regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humans.
• Use of a semen extender containing antibiotic to improve the fertility of a stallion with seminal vesiculitis due to Pseudomonas aeruginosa.
• Use of altrenogest to prepare ovariectomized mares as embryo transfer recipients.
• Use of an androgenized mare as an aid in detection of estrus in mares.
• Valproic acid enhances the efficacy of chemotherapy in EBV-positive tumors by increasing lytic viral gene expression.