Acute and Chronic Effects of Ramelteon in Rhesus Monkeys (Macaca mulatta): Dependence Liability Studies.

Acute and Chronic Effects of Ramelteon in Rhesus Monkeys (Macaca mulatta): Dependence Liability Studies. Research Abstract Details 

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Acute and Chronic Effects of Ramelteon in Rhesus Monkeys (Macaca mulatta): Dependence Liability Studies. Abstract Text:

Charles P France,Robert H Weltman,Wouter Koek,Christopher M Cruz,Lance R McMahon,

The acute and chronic effects of ramelteon, an MT-sub-1/MT-sub-2 receptor agonist, were evaluated in rhesus monkeys (Macaca mulatta) to assess discriminative stimulus effects in comparison with traditional benzodiazepine receptor agonists and to assess physical dependence potential. Discriminative effects of ramelteon were compared with midazolam in untreated monkeys and in diazepam-dependent monkeys that discriminated flumazenil. Dependence potential of ramelteon after daily 1-year administration (and intermittent discontinuation) was evaluated with standard operant procedures. Ramelteon did not produce benzodiazepine-like discriminative stimulus effects at doses up to 10 mg/kg. Long-term treatment or its discontinuation had no significant effect on spontaneous behavior, operant behavior, body weight, motor activity, or posture. These findings suggest that ramelteon is not likely to have benzodiazepine-like abuse or dependence liability. ((c) 2006 APA, all rights reserved).

Acute and Chronic Effects of Ramelteon in Rhesus Monkeys (Macaca mulatta): Dependence Liability Studies. Publishing Authors By Initials

CP France,RH Weltman,W Koek,CM Cruz,LR McMahon,

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Acute and Chronic Effects of Ramelteon in Rhesus Monkeys (Macaca mulatta): Dependence Liability Studies. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Behavioral neuroscience

VOLUME: 120

Page Numbers: 535-41

Journal Abbreviation: Behav. Neurosci.

ISSN: 0735-7044

DAY: 13

MONTH: Jun

YEAR: 2006

Acute and Chronic Effects of Ramelteon in Rhesus Monkeys (Macaca mulatta): Dependence Liability Studies. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX, US. france@uthscsa.edu.

Country: United States

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MEDLINETA: Behav Neurosci

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