Activity of Tumor Necrosis Factor-alpha (TNF-alpha) and its soluble type I receptor (p55TNF-R) in some drug-induced cutaneous reactions.

Activity of Tumor Necrosis Factor-alpha (TNF-alpha) and its soluble type I receptor (p55TNF-R) in some drug-induced cutaneous reactions. Research Abstract Details 

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Activity of Tumor Necrosis Factor-alpha (TNF-alpha) and its soluble type I receptor (p55TNF-R) in some drug-induced cutaneous reactions. Abstract Text:

Grazyna Chodorowska,Dorota Czelej,Marta Niewiedzio?,

Plasma concentration of TNF-alpha and its type I receptor (p55TNF-R) was examined in 126 patients with drug-induced skin reactions using immunoenzymatic ELISA method. Patients were subdivided into 6 groups: maculopapular eruptions (ME), erythema multiforme (EM), erythema multiforme coexisting with erythema nodosum (EMN), hyperergic vasculitis (HV), Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). In the acute clinical stage highly significant (p<0.001) or significant (p<0.01) elevation of mean plasma concentrations of the cytokine and its receptor was found in all examined groups in comparison with the control. Clearing of clinical symptoms was connected with considerable decrease (p<0.001, p<0.01) of mean plasma levels of the both proteins in comparison with the before treatment values. TNF-alpha concentrations still remained significantly more elevated than those observed in the control. The results indicate that plasma activity of TNF-alpha and its p55 receptor change with the clinical course of the examined drug-induced skin reactions, which suggests the partake of both proteins in the pathogenesis of these diseases.

Activity of Tumor Necrosis Factor-alpha (TNF-alpha) and its soluble type I receptor (p55TNF-R) in some drug-induced cutaneous reactions. Publishing Authors By Initials

G Chodorowska,D Czelej,M Niewiedzio?,

For similar cardiovascular diseases: vascular diseases: vasculitis research abstracts see: cardiovascular diseases: vascular diseases: vasculitis research

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Activity of Tumor Necrosis Factor-alpha (TNF-alpha) and its soluble type I receptor (p55TNF-R) in some drug-induced cutaneous reactions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annales Universitatis Mariae Curie-Sk?odowska. Sec

VOLUME: 58

Page Numbers: 50-6

Journal Abbreviation:

ISSN: 0066-2240

DAY: 21

MONTH: 01

YEAR: 2003

Activity of Tumor Necrosis Factor-alpha (TNF-alpha) and its soluble type I receptor (p55TNF-R) in some drug-induced cutaneous reactions. Information

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LANGUAGE: eng

NlmUniqueID: 414101

Activity of Tumor Necrosis Factor-alpha (TNF-alpha) and its soluble type I receptor (p55TNF-R) in some drug-induced cutaneous reactions. Keywords Mesh Terms:

KEYWORDS: Vasculitis

MESH TERMS: chemically induced

Chemical & Substance for Abstract: Activity of Tumor Necrosis Factor-alpha (TNF-alpha) and its soluble type I receptor (p55TNF-R) in some drug-induced cutaneous reactions. Information

Substance Name: TNFR-Fc fusion protein

Registry Number: 185243-69-0

Grant and Affiliation Information for Activity of Tumor Necrosis Factor-alpha (TNF-alpha) and its soluble type I receptor (p55TNF-R) in some drug-induced cutaneous reactions.

AFFILIATION: Chair and Department of Dermatology, Medical University of Lublin.

Country: Poland

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MEDLINETA: Ann Univ Mariae Curie Sklodows

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