Activity of 8.O.4'-neolignans against Trypanosoma cruzi.

Activity of 8.O.4'-neolignans against Trypanosoma cruzi. Research Abstract Details 

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Activity of 8.O.4'-neolignans against Trypanosoma cruzi. Abstract Text:

Isabel Nocito, Castelli,Susana A Zacchino,Esteban Serra,Isabel Nocito, Castelli,Susana A Zacchino,Esteban Serra,Isabel Nocito,María Victoria Castelli,Susana A Zacchino,Esteban Serra,

The in vitro evaluation of a series of 8.O.4'-neolignans (in their ketone, alcohol, and acetylated forms) on the proliferation of Trypanosoma cruzi led to the detection of three compounds with interesting activities against T. cruzi epimastigotes. These compounds also inhibited the in vitro differentiation of epimastigotes to trypomastigotes. When tested against HeLa cells, the same compounds did not affect the cell vitality and showed a low influence on cell viability as measured by dimethylthiazol diphenyltetrazolium bromide reduction. The three phenylpropanoid moieties tested did not show any activity against T. cruzi. One of the tested compounds, compound 4 (3,4-methylenedioxi7-oxo-1'-allyl-3',5'-dimethoxy-8.O.4'-neolignan) showed the best performance in both trypanocide and cytotoxic assays, suggesting that it should be considered as a leading structure for further research.

Activity of 8.O.4'-neolignans against Trypanosoma cruzi. Publishing Authors By Initials

I Nocito,MV Castelli,SA Zacchino,E Serra,I Nocito,MV Castelli,SA Zacchino,E Serra,I Nocito,MV Castelli,SA Zacchino,E Serra,

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Activity of 8.O.4'-neolignans against Trypanosoma cruzi. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Parasitology research

VOLUME: 101

Page Numbers: 1453-7

Journal Abbreviation: Parasitol. Res.

ISSN: 0932-0113

DAY: 17

MONTH: 08

YEAR: 2007

Activity of 8.O.4'-neolignans against Trypanosoma cruzi. Information

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LANGUAGE: eng

NlmUniqueID: 8703571

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AFFILIATION: Area Parasitología,Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina.

Country: Germany

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MEDLINETA: Parasitol Res

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