Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.

Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Research Abstract Details 

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Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Abstract Text:

Alexander A Chubykin,Deniz Atasoy,Mark R Etherton,Nils Brose,Ege T Kavalali,Jay R Gibson,Thomas C ,

Neuroligins enhance synapse formation in vitro, but surprisingly are not required for the generation of synapses in vivo. We now show that in cultured neurons, neuroligin-1 overexpression increases excitatory, but not inhibitory, synaptic responses, and potentiates synaptic NMDAR/AMPAR ratios. In contrast, neuroligin-2 overexpression increases inhibitory, but not excitatory, synaptic responses. Accordingly, deletion of neuroligin-1 in knockout mice selectively decreases the NMDAR/AMPAR ratio, whereas deletion of neuroligin-2 selectively decreases inhibitory synaptic responses. Strikingly, chronic inhibition of NMDARs or CaM-Kinase II, which signals downstream of NMDARs, suppresses the synapse-boosting activity of neuroligin-1, whereas chronic inhibition of general synaptic activity suppresses the synapse-boosting activity of neuroligin-2. Taken together, these data indicate that neuroligins do not establish, but specify and validate, synapses via an activity-dependent mechanism, with different neuroligins acting on distinct types of synapses. This hypothesis reconciles the overexpression and knockout phenotypes and suggests that neuroligins contribute to the use-dependent formation of neural circuits.

Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Publishing Authors By Initials

AA Chubykin,D Atasoy,MR Etherton,N Brose,ET Kavalali,JR Gibson,TC ,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuron

VOLUME: 54

Page Numbers: 919-31

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 21

MONTH: Jun

YEAR: 2007

Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Information

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LANGUAGE: eng

NlmUniqueID: 8809320

Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

Chemical & Substance for Abstract: Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Information

Substance Name: KN 93

Registry Number: 139298-40-1

Grant and Affiliation Information for Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.

AFFILIATION: Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.

Country: United States

AGENCY: United States NIMH

GRANT: R37 MH52804-08

ACRONYM: MH

MEDLINETA: Neuron

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