Activity dependent localization of synaptic NMDA receptors in spinal neurons.

Activity dependent localization of synaptic NMDA receptors in spinal neurons. Research Abstract Details 

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Activity dependent localization of synaptic NMDA receptors in spinal neurons. Abstract Text:

Kenneth M Rosen,Abhay Moghekar,Richard J O'Brien,

In cultured spinal neurons, NMDA receptors are absent from excitatory synapses under basal conditions, but can be made to appear at excitatory synapses following blockade of excitatory synaptic activity. The activity dependent synaptic localization of NMDA receptors is critically dependent on both the gradual, global accumulation of the NR2A and NR2B subunits and on a rapid, surface redistribution phase that is primed by the accumulation of NR2A and NR2B and inhibited by synaptic activity. Global changes in NR2A and NR2B accumulation and heterogeneous increases in synaptic NMDA receptor localization can also result from inhibitors of proteasomal processing, from manipulations of proteasomal subunit composition and from media conditioned by neurons undergoing synaptic scaling. While proteasomal processing is a mechanism shared with AMPA receptor scaling in cultured spinal neurons, diffusible factors, heterogeneity, and a rapid surface redistribution phase appear to be unique to activity dependent synaptic NMDA receptor localization.

Activity dependent localization of synaptic NMDA receptors in spinal neurons. Publishing Authors By Initials

KM Rosen,A Moghekar,RJ O'Brien,

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

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Activity dependent localization of synaptic NMDA receptors in spinal neurons. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular neurosciences

VOLUME: 34

Page Numbers: 578-91

Journal Abbreviation: Mol. Cell. Neurosci.

ISSN: 1044-7431

DAY: 29

MONTH: 12

YEAR: 2006

Activity dependent localization of synaptic NMDA receptors in spinal neurons. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9100095

Activity dependent localization of synaptic NMDA receptors in spinal neurons. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: metabolism

Chemical & Substance for Abstract: Activity dependent localization of synaptic NMDA receptors in spinal neurons. Information

Substance Name: Proteasome Endopeptidase Complex

Registry Number: EC 3.4.25.1

Grant and Affiliation Information for Activity dependent localization of synaptic NMDA receptors in spinal neurons.

AFFILIATION: Department of Neurology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01NS037694

ACRONYM: NS

MEDLINETA: Mol Cell Neurosci

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