Activity coregulates quantal AMPA and NMDA currents at neocortical synapses.

Activity coregulates quantal AMPA and NMDA currents at neocortical synapses. Research Abstract Details 

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Activity coregulates quantal AMPA and NMDA currents at neocortical synapses. Abstract Text:

AMPA and NMDA receptors are coexpressed at many central synapses, but the factors that control the ratio of these two receptors are not well understood. We recorded mixed miniature or evoked synaptic currents arising from coactivation of AMPA and NMDA receptors and found that long-lasting changes in activity scaled both currents up and down proportionally through changes in the number of postsynaptic receptors. The ratio of NMDA to AMPA current was similar at different synapses onto the same neuron, and this relationship was preserved following activity-dependent synaptic scaling. These data show that AMPA and NMDA receptors are tightly coregulated by activity at synapses at which they are both expressed and suggest that a mechanism exists to actively maintain a constant receptor ratio across a neuron's synapses.

Activity coregulates quantal AMPA and NMDA currents at neocortical synapses. Publishing Authors By Initials

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Activity coregulates quantal AMPA and NMDA currents at neocortical synapses. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuron

VOLUME: 26

Page Numbers: 659-70

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 26

MONTH: Jun

YEAR: 2000

Activity coregulates quantal AMPA and NMDA currents at neocortical synapses. Information

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LANGUAGE: eng

NlmUniqueID: 8809320

Activity coregulates quantal AMPA and NMDA currents at neocortical synapses. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

Chemical & Substance for Abstract: Activity coregulates quantal AMPA and NMDA currents at neocortical synapses. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for Activity coregulates quantal AMPA and NMDA currents at neocortical synapses.

AFFILIATION: Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA.

Country: UNITED STATES

AGENCY: United States NINDS

GRANT: R01 NS36853

ACRONYM: NS

MEDLINETA: Neuron

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