Active internal re-warming using a centrifugal pump and heat exchanger following haemorrhagic shock, surgical trauma and hypothermia in a porcine model.

Active internal re-warming using a centrifugal pump and heat exchanger following haemorrhagic shock, surgical trauma and hypothermia in a porcine model. Research Abstract Details 

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Active internal re-warming using a centrifugal pump and heat exchanger following haemorrhagic shock, surgical trauma and hypothermia in a porcine model. Abstract Text:

Naisan Garraway,D Ross Brown,David Nash,Andrew Kirkpatrick,Nathan P Schneidereit,Rardi Van Heest,Hamish Hwang,Richard Simons,

BACKGROUND: The centrifugal vortex blood pump (CVBP) using heparin-bonded circuitry allows re-warming of hypothermic trauma patients without anticoagulation. Study objectives were to confirm efficacy, and to characterise the physiology of CVBP re-warming in a porcine model. METHODS: Sixteen pigs were randomised to conventional or CVBP re-warming. They were bled to a mean arterial pressure of 30 mmHg and cooled to 29 degrees C. A physiological analysis was recorded during resuscitation to normo-tension and re-warming back to 37 degrees C. RESULTS: CVBP animals re-warmed significantly faster: 85.0+16.4 min versus 217.4+49.3 min (p<0.0001). Activated clotting time was significantly elevated in both groups at 29 degrees C with a marked trend to normalise faster in CVBP pigs. The peak cardiac index (CI) was significantly lower (1.14+0.68 versus 4.83+1.50 L/(min m2), while the systemic vascular resistance (SVR) was significantly higher (4239.9+1173.0 versus 1472.6+451.2 dyn x S x m2/cm5) with CVBP (p<0.001). CONCLUSION: CVBP is simple and very effective at re-warming hypothermic animals and may also reverse coagulopathy more quickly. Physiological derangements of elevated SVR and diminished CI require further study to elaborate underlying aetiology, and define optimal re-warming strategies.

Active internal re-warming using a centrifugal pump and heat exchanger following haemorrhagic shock, surgical trauma and hypothermia in a porcine model. Publishing Authors By Initials

N Garraway,DR Brown,D Nash,A Kirkpatrick,NP Schneidereit,R Van Heest,H Hwang,R Simons,

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Active internal re-warming using a centrifugal pump and heat exchanger following haemorrhagic shock, surgical trauma and hypothermia in a porcine model. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Injury

VOLUME: 38

Page Numbers: 1039-46

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ISSN: 0020-1383

DAY: 21

MONTH: 06

YEAR: 2007

Active internal re-warming using a centrifugal pump and heat exchanger following haemorrhagic shock, surgical trauma and hypothermia in a porcine model. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Active internal re-warming using a centrifugal pump and heat exchanger following haemorrhagic shock, surgical trauma and hypothermia in a porcine model.

AFFILIATION: Section of Trauma, Division of General Surgery, University of British Columbia, Vancouver, BC, Canada. garraway@telus.net

Country: Netherlands

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MEDLINETA: Injury

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