Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Research Abstract Details 

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Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Abstract Text:

Celina Demers,Chandra-Prakash Chaturvedi,Jeffrey A Ranish,Gaetan Juban,Patrick Lai,Francois Morle,Ruedi Aebersold,F Jeffrey Dilworth,Mark Groudine,Marjorie Brand,

MLL-containing complexes methylate histone H3 at lysine 4 (H3K4) and have been implicated in the regulation of transcription. However, it is unclear how MLL complexes are targeted to specific gene loci. Here, we show that the MLL2 complex associates with the hematopoietic activator NF-E2 in erythroid cells and is important for H3K4 trimethylation and maximal levels of transcription at the beta-globin locus. Furthermore, recruitment of the MLL2 complex to the beta-globin locus is dependent upon NF-E2 and coincides spatio-temporally with NF-E2 binding during erythroid differentiation. Thus, a DNA-bound activator is important initially for guiding MLL2 to a particular genomic location. Interestingly, while the MLL2-associated subunit ASH2L is restricted to the beta-globin locus control region 38 kb upstream of the beta(maj)-globin gene, the MLL2 protein spreads across the beta-globin locus, suggesting a previously undefined mechanism by which an activator influences transcription and H3K4 trimethylation at a distance.

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Publishing Authors By Initials

C Demers,CP Chaturvedi,JA Ranish,G Juban,P Lai,F Morle,R Aebersold,FJ Dilworth,M Groudine,M Brand,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular cell

VOLUME: 27

Page Numbers: 573-84

Journal Abbreviation: Mol. Cell

ISSN: 1097-2765

DAY: 17

MONTH: Aug

YEAR: 2007

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9802571

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: deficiency

Chemical & Substance for Abstract: Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Information

Substance Name: Methyltransferases

Registry Number: EC 2.1.1.-

Grant and Affiliation Information for Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

AFFILIATION: Sprott Center for Stem Cell Research, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.

Country: United States

AGENCY: United States NHLBI

GRANT: N01-HV-28179

ACRONYM: HV

MEDLINETA: Mol Cell

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