Activation of TGF-beta1 Through Up-Regulation of TSP-1 by Retinoic Acid in Retinal Pigment Epithelial Cells.

Activation of TGF-beta1 Through Up-Regulation of TSP-1 by Retinoic Acid in Retinal Pigment Epithelial Cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Activation of TGF-beta1 Through Up-Regulation of TSP-1 by Retinoic Acid in Retinal Pigment Epithelial Cells. Abstract Text:

Hiroko Uchida,Motomu Kuroki,Tomomi Shitama,Hideyuki Hayashi,Masahide Kuroki,Hiroko Uchida,Motomu Kuroki,Tomomi Shitama,Hideyuki Hayashi,Masahide Kuroki,

Purpose: Retinoic acid (RA) affects the activation of transforming growth factor-beta 1 (TGF-beta 1) in a variety of cells. We have previously shown that thrombospondin-1 (TSP-1) expression in retinal pigment epithelial (RPE) cells is up-regulated by RA. Since TSP-1 activates TGF-beta 1, we investigated whether RA stimulates the activation of TGF-beta 1 through up-regulation of TSP-1 in RPE cells. Methods: Human RPE cells were cultured with RA or TSP-1. The active form of TGF-beta 1 in the culture medium was measured by enzyme-linked immunosorbent assay. Results: The active form of TGF-beta 1 was increased dose-dependently by RA or TSP-1. The activation of TGF-beta 1 by RA was significantly hampered by an anti-TSP-1 antibody. Also, antibodies against integrins alpha vbeta 3 and alpha vbeta 5 inhibited the activation of TGF-beta 1.Conclusions: These findings suggest that, in RPE cells, RA increases the activation of TGF-beta 1 via up-regulation of TSP-1, and integrins such as alpha vbeta 3 and alpha vbeta 5 are essential in this activation step.

Activation of TGF-beta1 Through Up-Regulation of TSP-1 by Retinoic Acid in Retinal Pigment Epithelial Cells. Publishing Authors By Initials

H Uchida,M Kuroki,T Shitama,H Hayashi,M Kuroki,H Uchida,M Kuroki,T Shitama,H Hayashi,M Kuroki,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Activation of TGF-beta1 Through Up-Regulation of TSP-1 by Retinoic Acid in Retinal Pigment Epithelial Cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current eye research

VOLUME: 33

Page Numbers: 199-203

Journal Abbreviation: Curr. Eye Res.

ISSN: 0271-3683

DAY: 22

MONTH: Feb

YEAR: 2008

Activation of TGF-beta1 Through Up-Regulation of TSP-1 by Retinoic Acid in Retinal Pigment Epithelial Cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8104312

Activation of TGF-beta1 Through Up-Regulation of TSP-1 by Retinoic Acid in Retinal Pigment Epithelial Cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Activation of TGF-beta1 Through Up-Regulation of TSP-1 by Retinoic Acid in Retinal Pigment Epithelial Cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Activation of TGF-beta1 Through Up-Regulation of TSP-1 by Retinoic Acid in Retinal Pigment Epithelial Cells.

AFFILIATION: Department of Ophthalmology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Curr Eye Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Activation of TGF-beta1 Through Up-Regulation of TSP-1 by Retinoic Acid in Retinal Pigment Epithelial Cells Related Publications

• Activation of TGF-beta1 Through Up-Regulation of TSP-1 by Retinoic Acid in Retinal Pigment Epithelial Cells.
• Association between the expression of chemokine receptors CCR7 and CXCR3, and lymph node metastatic potential in lung adenocarcinoma.
• Autoantibody to alanyl-tRNA synthetase in patients with idiopathic pulmonary fibrosis.
• Autogenous osteochondral grafting for treatment of stifle osteochondrosis in dogs.
• Binding of annexins to lung lamellar bodies and the PMA-stimulated secretion of annexin V from alveolar type II cells.
• Cancer-targeting gene therapy using tropism-modified adenovirus.
• Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors.
• Correlation between lymph node metastasis and the expression of VEGF-C, VEGF-D and VEGFR-3 in T1 lung adenocarcinoma.
• Expression of the extracellular region of the human interleukin-4 receptor alpha chain and interleukin-13 receptor alpha1 chain by a silkworm-baculovirus system.
• Fasciitis: what is the significance of various forms?
• Femoral component wear in retrieved hip prostheses.
• Histological analysis of induced cartilage on the biodegradable or nonbiodegradable membranes from immature muscular tissue in vitro.
• In vivo change of elastic property in polyethylene acetabular components.
• Life cycle of Tritrichomonas muris.
• Prevention of acute lung allograft rejection in rat by the janus kinase 3 inhibitor, tyrphostin AG490.
• Prevention of tourniquet pain by subcutaneous injection into the posterior half of the axilla.
• Protein kinase C eta (PKC eta): its involvement in keratinocyte differentiation.
• Selective up-regulation of claudin-1 and claudin-2 in colorectal cancer.
• Severity of Measles among Patients with Incidental Postexposure Vaccination.
• The effect of positive emotion on infants' gaze shift.
• The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A.
• [An outbreak of cryptosporidiosis associated with swimming pools]
• [Changes of alkaline phosphatase in the blood in liver diseases treated with cyanocobalamine.]