Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes.

Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. Abstract Text:

Emese ,Eszter ,Katarina Vargova,Eszter Pankotai,Kanneganti Murthy,Zsuzsanna , , ,Katalin Fekete, Kiss, ,Zsombor Lacza,Domokos ,Csaba ,

Reactive free radical and oxidant production leads to DNA damage during myocardial ischemia/reperfusion. Consequent overactivation of poly(ADP-ribose) polymerase (PARP) promotes cellular energy deficit and necrosis. We hypothesized that PARP is activated in circulating leukocytes in patients with myocardial infarction and reperfusion during primary percutaneous coronary intervention (PCI). In 15 patients with ST segment elevation acute myocardial infarction, before and after primary PCI and 24 and 96 h later, we determined serum hydrogen peroxide concentrations, plasma levels of the oxidative DNA adduct 8-hydroxy-2'-deoxyguanosine (8OHdG), tyrosine nitration, PARP activation, and translocation of apoptosis-inducing factor (AIF) in circulating leukocytes. Plasma 8OHdG levels and leukocyte tyrosine nitration were rapidly increased by PCI. Similarly, poly(ADP-ribose) content of the leukocytes increased in cells isolated just after PCI, indicating immediate PARP activation triggered by reperfusion of the myocardium. In contrast, serum hydrogen peroxide concentrations and the translocation of AIF gradually increased over time and were most pronounced at 96 h. Reperfusion-related oxidative/nitrosative stress triggers DNA damage, which leads to PARP activation in circulating leukocytes. Translocation of AIF and lipid peroxidation occurs at a later stage. These results represent the first direct demonstration of PARP activation in human myocardial infarction. Future work is required to test whether pharmacological inhibition of PARP may offer myocardial protection during primary PCI.

Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. Publishing Authors By Initials

E ,E ,K Vargova,E Pankotai,K Murthy,Z ,T ,T ,K Fekete,RG Kiss,I ,Z Lacza,D ,C ,

For similar amino acids, peptides, and proteins: amino acids: amino acids, cyclic: amino acids, aromatic: tyrosine research abstracts see: amino acids, peptides, and proteins: amino acids: amino acids, cyclic: amino acids, aromatic: tyrosine research

PUBMED ID PMID:

MEDLINE DATE: 2006 Sep-Oct

Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular medicine (Cambridge, Mass.)

VOLUME: 12

Page Numbers: 221-8

Journal Abbreviation: Mol. Med.

ISSN: 1076-1551

DAY: 3

MONTH: 12

YEAR: 2007

Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9501023

Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. Keywords Mesh Terms:

KEYWORDS: Tyrosine

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes. Information

Substance Name: Poly(ADP-ribose) Polymerases

Registry Number: EC 2.4.2.30

Grant and Affiliation Information for Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes.

AFFILIATION: Cardiovascular Research Group of the Hungarian Academy of Sciences and Semmelweis University & National Health Center, Budapest, Hungary.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM60915

ACRONYM: GM

MEDLINETA: Mol Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Activation of polyADP-ribose polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes Related Publications

• 5'- O -Demethylnarcotine: A New Alkaloid from Papaver somniferum.
• A phase I study of myo-inositol for lung cancer chemoprevention.
• A time-resolved fluorescence study of 4',6'-diamidine-2-phenylindole dihydrochloride binding to polynucleotides.
• Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes.
• Activation of the poly(ADP-ribose) polymerase pathway in human heart failure.
• Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes.
• Antiandrogenic effect of isotretinoin: Is the retina involved in mechanism of action?
• Bipolar saline TURP for large prostate glands.
• Characterization of Staphylococcus aureus strains isolated from bovine milk in Hungary.
• Competing associations in bacterial warfare with two toxins.
• Computer-aided spectrophotometric determination of multicomponent drugs.
• Cosegregation of gastrointestinal ulcers and schizophrenia in a large national inpatient discharge database: revisiting the "brain-gut axis" hypothesis in ulcer pathogenesis.
• Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury.
• Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function.
• Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection.
• Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice.
• Long-term outcomes of dorsal intercarpal ligament capsulodesis for chronic scapholunate dissociation.
• MUC1 is a novel marker for the type II pneumocyte lineage during lung carcinogenesis.
• Model-Based Receptor Quantization Analysis for PET Parametric Imaging.
• Oxidant-induced cardiomyocyte injury: identification of the cytoprotective effect of a dopamine 1 receptor agonist using a cell-based high-throughput assay.
• Petasis Borono-Mannich reaction and allylation of carbonyl compounds via transient allyl boronates generated by palladium-catalyzed substitution of allyl alcohols. an efficient one-pot route to stereodefined alpha-amino acids and homoallyl alcohols.
• Poly(ADP-Ribose) polymerase inhibition improves endothelial dysfunction induced by hypochlorite.
• Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro.
• Ribonucleoprotein-masked nicks at 50-kbp intervals in the eukaryotic genomic DNA.
• Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors.
• Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction.
• Single nucleotide polymorphism: is it only genetic palmistry?
• Single-molecule FRET with diffusion and conformational dynamics.
• The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial.
• Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection.