Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells.

Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. Research Abstract Details 

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Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. Abstract Text:

O S Bang,J H Park,S S Kang,

Vitamin E-succinate (VES) induced HL-60 human leukemia cells to undergo apoptosis. Treatment with VES induced membrane translocation of Fas; cleavages of caspase-3, PARP, and lamin B; hypophosphorylation of retinoblastoma protein; and increase of p21(WAF1) protein level. During the induction of apoptosis, activity of PKC was gradually increased with downregulation of VES-induced ERK activity and accompanied by activation of caspase-3. Inhibition of PKC by GF109203X blocked VES-mediated membrane translocation of PKC-alpha and cleavage of caspase-3 cascade, resulting in prevention of VES-induced apoptosis. On the contrary, PKC activation by cotreatment with LPC or thapsigargin and VES synergistically increased VES-mediated apoptosis. However, inhibition of ERK activity by PD98059 showed no significant effect on VES-induced PKC activity and apoptosis. Taken together, our data suggest that VES induces activation of PKC and PKC-dependent hypophosphorylation of retinoblastoma protein, which results in induction of apoptosis, and that VES-induced early activation of ERK and ERK-dependent induction of p21(WAF1) are not required for apoptosis.

Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. Publishing Authors By Initials

OS Bang,JH Park,SS Kang,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 288

Page Numbers: 789-97

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 9

MONTH: Nov

YEAR: 2001

Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. Information

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LANGUAGE: eng

NlmUniqueID: 372516

Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. Information

Substance Name: Caspases

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells.

AFFILIATION: Department of Biology, College of Natural Sciences, Kyungpook National University, Taegu, 702-701, Korea.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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