Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor.

Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor. Research Abstract Details 

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Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor. Abstract Text:

B Liu,S Nakashima,H Kanoh,T Takano,T Shimizu,Y Nozawa,

Platelet-activating factor (PAF) activated phospholipase D (PLD) in WT-H cells, CHO cells stably expressing cloned guinea-pig PAF receptor. The PLD activation was found to be dependent on extracellular Ca2+, protein kinase C (PKC), and a currently unidentified protein tyrosine kinase (PTK). PTK inhibitors ST-638 and genistein inhibited PLD activation induced by PAF as well as phorbol myristate acetate, indicating that PTK acts downstream of PKC. Furthermore, activation of MAP (mitogen-activated protein) kinases, as assessed by their phosphorylation, was also dependent on Ca2+, PKC, and PTK. The correlation between PLD activity and MAP kinase activation, together with the previously observed MAP kinase activation associated with arachidonic acid release by cPLA2 [Honda et al. (1994) J. Biol. Chem. 269, 2307-2315], led us to examine the involvement of MAP kinase in PLD activation. The results indicate that PLD and MAP kinases are activated through the common pathway consisting of Ca2+, PKC, and the unidentified PTK, which act in parallel, but not in a linear sequence.

Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor. Publishing Authors By Initials

B Liu,S Nakashima,H Kanoh,T Takano,T Shimizu,Y Nozawa,

For similar chemical and pharmacologic phenomena: stimulation, chemical research abstracts see: chemical and pharmacologic phenomena: stimulation, chemical research

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Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 116

Page Numbers: 882-91

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Oct

YEAR: 1994

Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor. Keywords Mesh Terms:

KEYWORDS: Stimulation, Chemical

MESH TERMS: physiology

Chemical & Substance for Abstract: Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor. Information

Substance Name: Phospholipase D

Registry Number: EC 3.1.4.4

Grant and Affiliation Information for Activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating factor receptor.

AFFILIATION: Department of Biochemistry, Gifu University School of Medicine.

Country: JAPAN

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MEDLINETA: J Biochem

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