Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin.

Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin. Research Abstract Details 

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Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin. Abstract Text:

Fred Haugen,Christian A Drevon,

Adipose tissue secretes a wide range of hormones named adipokines, and these may play a role in obesity-related inflammation. Adiponectin is an exceptional adipokine because low plasma concentrations are associated with obesity, type 2 diabetes, and cardiovascular diseases. It has been observed that plasma adiponectin concentrations are elevated during inflammatory conditions like preeclampsia and arthritis. Nuclear factor-kappaB (NF-kappaB) is an essential transcription factor for expression of inflammation-related proteins. We have used U937 cells stably transfected to express luciferase under the control of NF-kappaB to examine if adiponectin may modulate NF-kappaB activity. Physiological concentrations of native adiponectin induced NF-kappaB activity. This effect was relatively strong compared with proinflammatory adipokines like leptin, resistin, and IL-6. The enhanced NF-kappaB activity was attributed to the high molecular weight adiponectin isoforms. NF-kappaB was not activated by mutated adiponectin that is unable to form high molecular weight complexes. Furthermore, the C-terminal fragment, globular adiponectin, markedly increased NF-kappaB reporter activity, cytokine release, and mRNA expression of inflammation marker genes, at higher levels than stimulation with TNF-alpha and lipopolysaccharide. NF-kappaB activation by globular adiponectin was not affected by antibody inhibition of toll-like receptor 4 or TNF receptors 1 and 2 but was attenuated by inhibitors of p38 MAPK, phosphatidylinositol 3-kinase, and protein kinase C. Analyses of the p65 subunit of NF-kappaB in different leukocyte cell lines showed activation of two monocytic cell lines (U937 and THP-1) by native and globular adiponectin. Our results indicate that adiponectin has proinflammatory properties in monocytic cells.

Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin. Publishing Authors By Initials

F Haugen,CA Drevon,

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Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Endocrinology

VOLUME: 148

Page Numbers: 5478-86

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 16

MONTH: 08

YEAR: 2007

Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin. Information

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LANGUAGE: eng

NlmUniqueID: 375040

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Grant and Affiliation Information for Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin.

AFFILIATION: Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. fred.haugen@medisin.uio.no

Country: United States

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MEDLINETA: Endocrinology

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