Activation of mouse splenic lymphocyte guanylate cyclase by calcium ion.

Activation of mouse splenic lymphocyte guanylate cyclase by calcium ion. Research Abstract Details 

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Activation of mouse splenic lymphocyte guanylate cyclase by calcium ion. Abstract Text:

T Katagiri,T Terao,T Osawa,

The guanosine 3',5'-cyclic monophosphate (cGMP) level in the mouse splenic lymphocytes was increased about 2- to 3-fold by concanavalin A. This increase was completely dependent on the presence of Ca2+ in the medium. Homogenates of mouse splenic lymphocytes contained significant guanylate cyclase [EC 4.6.1.2] activity in both the 105,000 X g (60 min) particulate and supernatant fractions and both fractions required Mn2+ for full activity. Calcium ion (3mM) activated soluble guanylate cyclase 3-fold at a relatively low concentration of Mn2+ (less than 1mM) but inhibited the particulate enzyme slightly at all Mn2+ concentrations tested. Concanavalin A itself did not stimulate either fraction of guanylate cyclase. Thus these results suggest that elevation of the cGMP level in lymphocytes by concanavalin A might be brought about by stimulation of Ca2+ uptake and activation of soluble guanylate cyclase by the latter.

Activation of mouse splenic lymphocyte guanylate cyclase by calcium ion. Publishing Authors By Initials

T Katagiri,T Terao,T Osawa,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: mice research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: mice research

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Activation of mouse splenic lymphocyte guanylate cyclase by calcium ion. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 79

Page Numbers: 849-52

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Apr

YEAR: 1976

Activation of mouse splenic lymphocyte guanylate cyclase by calcium ion. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Activation of mouse splenic lymphocyte guanylate cyclase by calcium ion. Keywords Mesh Terms:

KEYWORDS: Mice

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Activation of mouse splenic lymphocyte guanylate cyclase by calcium ion. Information

Substance Name: Guanylate Cyclase

Registry Number: EC 4.6.1.2

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Country: JAPAN

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MEDLINETA: J Biochem

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