Activation of interferon-inducible genes in mice by poly rI:rC or alloantigens.

Activation of interferon-inducible genes in mice by poly rI:rC or alloantigens. Research Abstract Details 

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Activation of interferon-inducible genes in mice by poly rI:rC or alloantigens. Abstract Text:

We have examined the effects of synthetic dsRNA (poly rI:rC) treatment or of immunization with irradiated allogeneic cells on the expression in vivo of several interferon (IFN)-inducible genes. For this purpose, DBA/2 mice were injected i.p. once with poly rI:rC, or once and then again 3 weeks later, with irradiated C3H/He spleen cells and the effect of these treatments on the levels of the following mRNAs was determined: 202, 2',5'-oligoadenylate synthetase (2-5A synthetase), class I and class II major histocompatibility antigens, and beta-actin. After poly rl:rC treatment, the levels of the 202 and 2-5A synthetase mRNAs in the spleen and in the bone marrow peaked between 12 and 24 h and decreased thereafter. The class I mRNA levels started to increase at 12 h, peaked at 24 h, and declined thereafter. No increase in class II mRNA expression was observed after poly rl:rC injection, whereas beta-actin levels remained unchanged. Pretreatment of DBA/2 mice with sheep anti-murine IFN-alpha/beta antibodies before poly rI:rC injection strongly diminished the induction of 202 mRNA, indicating that IFN-alpha/beta mediated this induction. When irradiated C3H/He spleen cells were injected into DBA/2 mice, the class I and class II mRNAs in the spleen, but not in the bone marrow, started to increase at 12 h, peaked between 48 and 96 h, and decreased thereafter. No increase in the levels of 202 and 2-5A synthetase mRNAs was detected, whereas beta-actin levels remained unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)

Activation of interferon-inducible genes in mice by poly rI:rC or alloantigens. Publishing Authors By Initials

For similar tissues: lymphoid tissue: spleen research abstracts see: tissues: lymphoid tissue: spleen research

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Activation of interferon-inducible genes in mice by poly rI:rC or alloantigens. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunotherapy : official journal of the

VOLUME: 10

Page Numbers: 20-7

Journal Abbreviation: J. Immunother.

ISSN: 1053-8550

DAY: 18

MONTH: Feb

YEAR: 1991

Activation of interferon-inducible genes in mice by poly rI:rC or alloantigens. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9102704

Activation of interferon-inducible genes in mice by poly rI:rC or alloantigens. Keywords Mesh Terms:

KEYWORDS: Spleen

MESH TERMS: immunology

Chemical & Substance for Abstract: Activation of interferon-inducible genes in mice by poly rI:rC or alloantigens. Information

Substance Name: 2',5'-Oligoadenylate Synthetase

Registry Number: EC 2.7.7.-

Grant and Affiliation Information for Activation of interferon-inducible genes in mice by poly rI:rC or alloantigens.

AFFILIATION: Institute of Microbiology, Medical School, University of Torino, Italy.

Country: UNITED STATES

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MEDLINETA: J Immunother (1991)

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