Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells.

Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Research Abstract Details 

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Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Abstract Text:

Tatsuya Kato,Nagato Sato,Satoshi Hayama,Takumi Yamabuki,Tomoo Ito,Masaki Miyamoto,Satoshi Kondo,Yusuke Nakamura,Yataro Daigo,

We identified a novel gene HJURP (Holliday junction-recognizing protein) whose activation seemed to play a pivotal role in the immortality of cancer cells. HJURP was considered a possible downstream target for ataxia telangiectasia mutated signaling, and its expression was increased by DNA double-strand breaks (DSB). HJURP was involved in the homologous recombination pathway in the DSB repair process through interaction with hMSH5 and NBS1, which is a part of the MRN protein complex. HJURP formed nuclear foci in cells at S phase and those subjected to DNA damage. In vitro assays implied that HJURP bound directly to the Holliday junction and rDNA arrays. Treatment of cancer cells with small interfering RNA (siRNA) against HJURP caused abnormal chromosomal fusions and led to genomic instability and senescence. In addition, HJURP overexpression was observed in a majority of lung cancers and was associated with poor prognosis as well. We suggest that HJURP is an indispensable factor for chromosomal stability in immortalized cancer cells and is a potential novel therapeutic target for the development of anticancer drugs.

Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Publishing Authors By Initials

T Kato,N Sato,S Hayama,T Yamabuki,T Ito,M Miyamoto,S Kondo,Y Nakamura,Y Daigo,

For similar proteins: neoplasm proteins: tumor suppressor proteins research abstracts see: proteins: neoplasm proteins: tumor suppressor proteins research

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Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 8544-53

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 6

MONTH: 09

YEAR: 2007

Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Information

Substance Name: Protein-Serine-Threonine Kinases

Registry Number: EC 2.7.11.1

Grant and Affiliation Information for Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells.

AFFILIATION: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Country: United States

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MEDLINETA: Cancer Res

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