Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1.

Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1. Research Abstract Details 

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Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1. Abstract Text:

Previous studies have shown that infection of human fibroblasts with human cytomegalovirus (HCMV) results in activation of cellular interferon-responsive gene expression. We demonstrate here that infection of human fibroblasts with herpes simplex virus type 1 (HSV-1) in the absence of de novo protein synthesis also induces the expression of interferon-responsive genes. Five genes tested (encoding ISG54, IFI56, ISG15, 9-27 and MxA) were activated by infection with HSV-1, although the degree of response varied between the individual genes. HSV-1 was a less efficient inducer than HCMV. The effect was a consequence of binding of the virus particle to the cell surface or of the presence of virion components within the infected cell. Induction was mediated by a pathway other than the mechanism through which interferon-alpha mediates its effects on cellular gene expression.

Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1. Publishing Authors By Initials

For similar proteins: ubiquitins research abstracts see: proteins: ubiquitins research

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Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of general virology

VOLUME: 81

Page Numbers: 2215-8

Journal Abbreviation: J. Gen. Virol.

ISSN: 0022-1317

DAY: 6

MONTH: Sep

YEAR: 2000

Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1. Information

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LANGUAGE: eng

NlmUniqueID: 77340

Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1. Keywords Mesh Terms:

KEYWORDS: Ubiquitins

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1. Information

Substance Name: GTP-Binding Proteins

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1.

AFFILIATION: Medical Research Council Virology Unit, Church Street, Glasgow G11 5JR, UK.

Country: ENGLAND

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MEDLINETA: J Gen Virol

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