Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stress.

Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stress. Research Abstract Details 

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Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stress. Abstract Text:

Sang Woon Chung,Akira Toriba,Hae Young Chung,Byung Pal Yu,Takayuki Kameda,Ning Tang,Ryoichi Kizu,Kazuichi Hayakawa,Sang Woon Chung,Akira Toriba,Hae Young Chung,Byung Pal Yu,Takayuki Kameda,Ning Tang,Ryoichi Kizu,Kazuichi Hayakawa,Sang Woon Chung,Akira Toriba,Hae Young Chung,Byung Pal Yu,Takayuki Kameda,Ning Tang,Ryoichi Kizu,Kazuichi Hayakawa,

Quinoid polycyclic aromatic hydrocarbons are potent redox-active compounds that undergo enzymatic and nonenzymatic redox cycling with their semiquinone radical. We previously reported that acenaphthenequinone (AcQ) can damage human lung epithelial A549 cells through the formation of reactive species (RS). However, the biochemical mechanisms by which RS-generating enzymes cause oxidative burst during AcQ exposure remain elusive. Here we examined the biochemical mechanism of AcQ-induced RS generation by using selective metabolic inhibitors in A549 cells. We found that AA861, a 5-lipoxygenase (5-LO)-specific inhibitor significantly decreases RS generation. This inhibition of RS seems to be 5-LO specific because other inhibitors did not suppress AcQ-induced RS generation by nicotinamide adenine nucleotide phosphate (reduced) oxidase and/or xanthine oxidase. In addition, the inhibition of 5-LO by AA861 markedly reduced AcQ-induced nuclear factor kappa B (NF-kappa B) activation. We further found the activation of 5-LO pathway by exposing cells to AcQ mediates the secretion of inflammatory leukotriene B4, which can be significantly suppressed by a potent RS scavenger, N-acetylcysteine. Thus, based on our findings, we propose that AcQ-induced damage is likely due to increased RS generation and NF-kappa B activity through 5-LO activation.

Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stress. Publishing Authors By Initials

SW Chung,A Toriba,HY Chung,BP Yu,T Kameda,N Tang,R Kizu,K Hayakawa,SW Chung,A Toriba,HY Chung,BP Yu,T Kameda,N Tang,R Kizu,K Hayakawa,SW Chung,A Toriba,HY Chung,BP Yu,T Kameda,N Tang,R Kizu,K Hayakawa,

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Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stress. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Toxicological sciences : an official journal of th

VOLUME: 101

Page Numbers: 152-8

Journal Abbreviation: Toxicol. Sci.

ISSN: 1096-6080

DAY: 9

MONTH: 10

YEAR: 2007

Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stress. Information

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LANGUAGE: eng

NlmUniqueID: 9805461

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Grant and Affiliation Information for Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stress.

AFFILIATION: Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. chungsw@p.kanazawa-u.ac.jp

Country: United States

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MEDLINETA: Toxicol Sci

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