Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates.

Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. Research Abstract Details 

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Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. Abstract Text:

Shu Yuan Yang,Sebastian D Fugmann,Hillary S Gramlich,David G Schatz,

The molecular features that allow activation-induced cytidine deaminase (AID) to target Ig and certain non-Ig genes are not understood, although transcription has been implicated as one important parameter. We explored this issue by testing the mutability of a non-Ig transcription cassette in Ig and non-Ig loci of the chicken B cell line DT40. The cassette did not act as a stable long term mutation target but was able to be mutated in an AID-dependent manner for a limited time post-integration. This indicates that newly integrated DNA has molecular characteristics that render it susceptible to modification by AID, with implications for how targeting and mis-targeting of AID occurs.

Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. Publishing Authors By Initials

SY Yang,SD Fugmann,HS Gramlich,DG Schatz,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 25308-13

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 5

MONTH: 07

YEAR: 2007

Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: physiology

Chemical & Substance for Abstract: Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates. Information

Substance Name: Cytidine Deaminase

Registry Number: EC 3.5.4.5

Grant and Affiliation Information for Activation-induced cytidine deaminase-mediated sequence diversification is transiently targeted to newly integrated DNA substrates.

AFFILIATION: Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI066130

ACRONYM: AI

MEDLINETA: J Biol Chem

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