Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice.

Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice. Research Abstract Details 

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Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice. Abstract Text:

Simon Mantha,Maureen Ward,Jonathan McCafferty,Alan Herron,Teresa Palomero,Adolfo Ferrando,Arthur Bank,Christine Richardson,

Ikaros and Notch1 genes are critical to T-cell differentiation through transcriptional activation of target genes and interaction with chromatin remodeling complexes. An Ikaros (Plastic) point mutation inhibits activity of normal Ikaros and Ikaros family members, and leads to T-cell lymphoma in heterozygotes (Plstc/+). Analysis revealed Notch1 activating mutations in 12 of 17 Plstc/+ lymphomas (70%), analogous to those in human T-ALL. Mice acquired Notch1 mutations in lymph nodes as early as 7 weeks. Thus, combined Notch1 and Ikaros dysfunction can be a significant early event in T-cell proliferation and tumorigenesis.

Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice. Publishing Authors By Initials

S Mantha,M Ward,J McCafferty,A Herron,T Palomero,A Ferrando,A Bank,C Richardson,

For similar genetic processes: gene expression regulation: trans-activation (genetics) research abstracts see: genetic processes: gene expression regulation: trans-activation (genetics) research

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Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Leukemia research

VOLUME: 31

Page Numbers: 321-7

Journal Abbreviation: Leuk. Res.

ISSN: 0145-2126

DAY: 25

MONTH: 07

YEAR: 2006

Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7706787

Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice. Keywords Mesh Terms:

KEYWORDS: Trans-Activation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice. Information

Substance Name: Ikaros Transcription Factor

Registry Number: 148971-36-2

Grant and Affiliation Information for Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice.

AFFILIATION: Department of Medicine, Columbia University, New York, NY 10032, USA.

Country: England

AGENCY: United States NIDDK

GRANT: T32 DK-007373

ACRONYM: DK

MEDLINETA: Leuk Res

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