Action selection and refinement in subcortical loops through basal ganglia and cerebellum.

Action selection and refinement in subcortical loops through basal ganglia and cerebellum. Research Abstract Details 

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Action selection and refinement in subcortical loops through basal ganglia and cerebellum. Abstract Text:

J C Houk,C Bastianen,D Fansler,A Fishbach,D Fraser,P J Reber,S A Roy,L S Simo,

Subcortical loops through the basal ganglia and the cerebellum form computationally powerful distributed processing modules (DPMs). This paper relates the computational features of a DPM's loop through the basal ganglia to experimental results for two kinds of natural action selection. First, functional imaging during a serial order recall task was used to study human brain activity during the selection of sequential actions from working memory. Second, microelectrode recordings from monkeys trained in a step-tracking task were used to study the natural selection of corrective submovements. Our DPM-based model assisted in the interpretation of puzzling data from both of these experiments. We come to posit that the many loops through the basal ganglia each regulate the embodiment of pattern formation in a given area of cerebral cortex. This operation serves to instantiate different kinds of action (or thought) mediated by different areas of cerebral cortex. We then use our findings to formulate a model of the aetiology of schizophrenia.

Action selection and refinement in subcortical loops through basal ganglia and cerebellum. Publishing Authors By Initials

JC Houk,C Bastianen,D Fansler,A Fishbach,D Fraser,PJ Reber,SA Roy,LS Simo,

For similar nervous system: neurons research abstracts see: nervous system: neurons research

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Action selection and refinement in subcortical loops through basal ganglia and cerebellum. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Philosophical transactions of the Royal Society of

VOLUME: 362

Page Numbers: 1573-83

Journal Abbreviation: Philos. Trans. R. Soc. Lond.,

ISSN: 0962-8436

DAY: 29

MONTH: Sep

YEAR: 2007

Action selection and refinement in subcortical loops through basal ganglia and cerebellum. Information

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LANGUAGE: eng

NlmUniqueID: 7503623

Action selection and refinement in subcortical loops through basal ganglia and cerebellum. Keywords Mesh Terms:

KEYWORDS: Neurons

MESH TERMS: physiology

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Grant and Affiliation Information for Action selection and refinement in subcortical loops through basal ganglia and cerebellum.

AFFILIATION: Northwestern University Medical School, Chicago, IL 60208, USA. j-houk@northwestern.edu

Country: England

AGENCY: United States NINDS

GRANT: P01-NS44383

ACRONYM: NS

MEDLINETA: Philos Trans R Soc Lond B Biol

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