Action of topically applied arachidonic acid on the skin of patients with psoriasis.

Action of topically applied arachidonic acid on the skin of patients with psoriasis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Action of topically applied arachidonic acid on the skin of patients with psoriasis. Abstract Text:

Concentrations of arachidonic acid ranging from 0.1% to 2% were applied under occlusive dressings to psoriatic plaques in 45 patients. Alleviation of the clinical symptoms of psoriasis including complete clearing in some cases was obtained with the use of 0.5% to 2% arachidonic acid applied under occlusion every 24 to 48 hours five to seven times. Histologic examination showed polymorphonuclear leukocytes penetrating into the stratum corneum and formation of microabscesses or wide-spread accumulations of polymorphonuclear leukocytes in the stratum corneum, with its eventual destruction. The parakeratotic horny layer became detached; this was followed by restoration of the granular layer and an apparently normal stratum corneum. While arachidonic acid metabolites can be proinflammatory and proproliferative, they may also be important in the healing process for psoriasis.

Action of topically applied arachidonic acid on the skin of patients with psoriasis. Publishing Authors By Initials

For similar integumentary system: skin research abstracts see: integumentary system: skin research

PUBMED ID PMID:

MEDLINE DATE:

Action of topically applied arachidonic acid on the skin of patients with psoriasis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 124

Page Numbers: 387-91

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Mar

YEAR: 1988

Action of topically applied arachidonic acid on the skin of patients with psoriasis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

Action of topically applied arachidonic acid on the skin of patients with psoriasis. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: pathology

Chemical & Substance for Abstract: Action of topically applied arachidonic acid on the skin of patients with psoriasis. Information

Substance Name: Arachidonic Acid

Registry Number: 506-32-1

Grant and Affiliation Information for Action of topically applied arachidonic acid on the skin of patients with psoriasis.

AFFILIATION: Owen Laboratories, Fort Worth, Tex.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Arch Dermatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Action of topically applied arachidonic acid on the skin of patients with psoriasis Related Publications

• Action of topically applied arachidonic acid on the skin of patients with psoriasis.
• Correlations between alterations in length-dependent Ca(2+) activation of cardiac myofilaments and the end-systolic pressure-volume relation.
• Determination (monitoring) of PAHs in surface waters: why an operationally defined procedure is needed.
• Differential effects of isoflurane and ketamine/inactin anesthesia on cAMP and cardiac function in FVB/N mice during basal state and beta-adrenergic stimulation.
• Restriction map of Thiobacillus versutus plasmid pTAV1.
• [A case of cardiomyopathia hypertrophica obstructiva]
• [Anal leiomyoma]
• [Cardiomyopathia hypertrophica obstructiva]
• [Incidence of neoplasms in farm workers with enzootic leukemia]
• [Reduction in body weight during health resort treatment of obesity and diabetes mellitus]
• [The O. J. Simpson case. Guilty or innocent?]
• [Transformations aluminum hydroxide in adsorbed vaccines]