Action of Cis-dichlorodiammineplatinum(II) (NSC-119875) at ehe cellular level.

Action of Cis-dichlorodiammineplatinum(II) (NSC-119875) at ehe cellular level. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Action of Cis-dichlorodiammineplatinum(II) (NSC-119875) at ehe cellular level. Abstract Text:

B Drewinko,J A Gottlieb,

Asynchronous human lymphoma cells treated for 1 hour with increasing concentrations of cis-dichlorodiammineplatinum(II) revealed a marked decrease in survival as estimated by the colony-forming technique. When the treatmentwas extended for 8 hours at a concentration of 5micrograms/ml, a killing effect (greater than 3 log decades) was observed which was similar to that obtained when 50micrograms/ml is incubated with the cells for 1 hour. This finding suggests that better antitumor effects with fewer toxic effects may be obtained clinically by prolonged infusion of low doses of cis-dichlorodiammineplatinum (II). Synchronized lymphoma cells showed no significant degree of cell-cycle-stage sensitivity to cis-dichlorodiammineplatinum (II). The drug kills cells with similar efficiency in all stages of the cell cycle. No killing effect was elicited after incubation of the cells with spironolactone, a compound said to protect the kidneys from the toxic effects of heavy metals. However, simultaneous incubation of spironolactone and cis-dichlorodiammineplatinum (II) did not prevent the lethal action of the second drug. If spironolactone is proven to be an inhibitor of cis-dichlorodiammineplatinum (II) nephrotoxicity, it will become a valuable addition to the treatment of human neoplasia with this platinum compound. Lymphoma cells given a "priming" dose of 10 micrograms/ml of cis-dichlorodiammineplatinum (II) failed to repair the induced damage. A second exposure to 10 micrograms/ml of the drug at various subsequent intervals elicited greater killing effect than that produced by 20 micrograms/ml given at one time. A clear synergistic effect was noted when cis-dichlorodiammineplatinum (II) was given simultaneously with camptothecin or BCNU. The molecular mechanism by which this effect is accomplished is not presently apparent.

Action of Cis-dichlorodiammineplatinum(II) (NSC-119875) at ehe cellular level. Publishing Authors By Initials

B Drewinko,JA Gottlieb,

For similar organic chemicals: lactones: spironolactone research abstracts see: organic chemicals: lactones: spironolactone research

PUBMED ID PMID:

MEDLINE DATE: 1975 May-Jun

Action of Cis-dichlorodiammineplatinum(II) (NSC-119875) at ehe cellular level. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer chemotherapy reports. Part 1

VOLUME: 59

Page Numbers: 665-73

Journal Abbreviation:

ISSN: 0069-0112

DAY: 20

MONTH: 02

YEAR: 2008

Action of Cis-dichlorodiammineplatinum(II) (NSC-119875) at ehe cellular level. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7607105

Action of Cis-dichlorodiammineplatinum(II) (NSC-119875) at ehe cellular level. Keywords Mesh Terms:

KEYWORDS: Spironolactone

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Action of Cis-dichlorodiammineplatinum(II) (NSC-119875) at ehe cellular level. Information

Substance Name: Camptothecin

Registry Number: 7689-03-4

Grant and Affiliation Information for Action of Cis-dichlorodiammineplatinum(II) (NSC-119875) at ehe cellular level.

AFFILIATION:

Country: UNITED STATES

AGENCY: United States NCI

GRANT: N01-CM-61156

ACRONYM: CM

MEDLINETA: Cancer Chemother Rep

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Action of Cis-dichlorodiammineplatinumII NSC-119875 at ehe cellular level Related Publications

• (2E,4E)-N-Isobutyl-9-piperonyl-nona-2,4-dienoic Amide from Ottonia anisum*.
• A case of lipoidosis of the stomach.
• A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria.
• Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study.
• Cardiac autonomic function in older adults with sleep-disordered breathing.
• Cardiac autonomic function in older adults with sleep-disordered breathing.
• Cardiolipin: setting the beat of apoptosis.
• Creating accountable care organizations: the extended hospital medical staff.
• Dihydropiplartine from Piper bartlingianum*.
• Dr. Eugene L. Gottlieb on 40 years of JCO. Interview by Robert G. Keim.
• Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes.
• Establishment of testicular endocrine function impairment during childhood and puberty in boys with Klinefelter syndrome.
• Failure to achieve a threshold dose of CD34+ CD110+ progenitor cells in the graft predicts delayed platelet engraftment after autologous stem cell transplantation.
• Heart mitochondria: gates of life and death.
• Hemostasis with absorbable material in operations on the foot.
• Language barriers surrounding medication use among older Latinos.
• Not Available
• Polony analysis of gene expression in ES cells and blastocysts.
• Poverty and human development.
• The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco/endoplasmic reticulum calcium stores.
• The biological degradation of lignin; utilization of lignin by fungi.
• The family wellness warriors initiative.
• The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: apoptosis meets autophagy.
• The pancreas in familial adenomatous polyposis.
• The thoracoacromial trunk: alternative recipient vessels in reoperative head and neck reconstructive microsurgery.
• The use of alkaline dentifrices and alkaline mouthwashes for caries reduction.
• The use of sodium amytal and benzedrine sulfate in the symptomatic treatment of depressions.
• The wisdom of robins. Cultivating the "grown and flown" patient.
• VITAMIN "B" COMPLEX DEFICIENCY AS A CAUSE OF RETROBULBAR NEURITIS AND PERIPHERAL NEURITIS IN A CHRONIC ALCOHOLIC AND PIPE SMOKER.
• [Not Available.]