Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats.

Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats. Research Abstract Details 

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Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats. Abstract Text:

Junji Takayama,Masanori Takaoka,Shinya Yamamoto,Asami Nohara,Mamoru Ohkita,Yasuo Matsumura,Junji Takayama,Masanori Takaoka,Shinya Yamamoto,Asami Nohara,Mamoru Ohkita,Yasuo Matsumura,

We investigated the effects of actinonin, an inhibitor of a matrix-degrading enzyme meprin, on ischemic acute kidney injury in male and female rats, and these were compared with the effects of verapamil, a Ca(2+) channel blocker. Ischemic acute kidney injury was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. At 24 h after reperfusion, renal function and histology of both males and females showed significant deterioration. The degrees of renal dysfunction and histological damage were much more severe in males than in females. Pre-ischemic treatment with actinonin (10 or 30 mg/kg, i.v.) dose-dependently attenuated the ischemia/reperfusion-induced renal injury in male rats, but failed to improve the renal injury in female rats. On the other hand, verapamil (1 mg/kg, i.v.) could efficiently prevent the ischemic acute kidney injury in female rats, as well as male rats. These results indicate that the renoprotective effect of actinonin is male-specific, thereby suggesting that meprin is involved in exacerbation of ischemia/reperfusion-induced renal injury in male rats. The possibility that meprin is a key factor involved in the sex difference in the pathogenesis of ischemic acute kidney injury, warrants further attention.

Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats. Publishing Authors By Initials

J Takayama,M Takaoka,S Yamamoto,A Nohara,M Ohkita,Y Matsumura,J Takayama,M Takaoka,S Yamamoto,A Nohara,M Ohkita,Y Matsumura,

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Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of pharmacology

VOLUME: 581

Page Numbers: 157-63

Journal Abbreviation: Eur. J. Pharmacol.

ISSN: 0014-2999

DAY: 28

MONTH: 11

YEAR: 2007

Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats.

AFFILIATION: Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.

Country: Netherlands

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MEDLINETA: Eur J Pharmacol

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