Actin filament organization of foot processes in vertebrate glomerular podocytes.

Actin filament organization of foot processes in vertebrate glomerular podocytes. Research Abstract Details 

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Actin filament organization of foot processes in vertebrate glomerular podocytes. Abstract Text:

Koichiro Ichimura,Hidetake Kurihara,Tatsuo Sakai,

We investigated the actin filament organization and immunolocalization of actin-binding proteins (alpha-actinin and cortactin) in the podocyte foot processes of eight vertebrate species (lamprey, carp, newt, frog, gecko, turtle, quail, and rat). Three types of actin cytoskeleton were found in these foot processes. (1) A cortical actin network with cortactin filling the space between the plasma membrane and the other actin cytoskeletons described below was found in all of the species examined here. The data indicated that the cortical actin network was the minimal essential actin cytoskeleton for the formation and maintenance of the foot processes in vertebrate podocytes. (2) An actin bundle with alpha-actinin existing along the longitudinal axis of foot process above the level of slit diaphragms was only observed in quail and rat. (3) An actin fascicle consisting of much fewer numbers of actin filaments than that of the actin bundle was observed in the species other than quail and rat, but at various frequencies. These findings suggest that the actin bundle is an additional actin cytoskeleton reflecting a functional state peculiar to quail and rat glomeruli. Considering the higher intraglomerular pressure and the extremely thin filtration barrier in birds and mammals, the foot processes probably mainly protect the thinner filtration barrier from the higher internal pressure occurring in quail and rat glomeruli. Therefore, we consider that the actin bundle plays a crucial role in the mechanical protection of the filtration barrier. Moreover, the actin fascicle may be a potential precursor of the actin bundle.

Actin filament organization of foot processes in vertebrate glomerular podocytes. Publishing Authors By Initials

K Ichimura,H Kurihara,T Sakai,

For similar animals: chordata: vertebrates research abstracts see: animals: chordata: vertebrates research

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Actin filament organization of foot processes in vertebrate glomerular podocytes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell and tissue research

VOLUME: 329

Page Numbers: 541-57

Journal Abbreviation: Cell Tissue Res.

ISSN: 0302-766X

DAY: 29

MONTH: 06

YEAR: 2007

Actin filament organization of foot processes in vertebrate glomerular podocytes. Information

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LANGUAGE: eng

NlmUniqueID: 417625

Actin filament organization of foot processes in vertebrate glomerular podocytes. Keywords Mesh Terms:

KEYWORDS: Vertebrates

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Actin filament organization of foot processes in vertebrate glomerular podocytes. Information

Substance Name: Actinin

Registry Number: 11003-00-2

Grant and Affiliation Information for Actin filament organization of foot processes in vertebrate glomerular podocytes.

AFFILIATION: Department of Anatomy, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. ichimura@med.juntendo.ac.jp

Country: Germany

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MEDLINETA: Cell Tissue Res

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