Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake.

Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake. Research Abstract Details 

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Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake. Abstract Text:

Jennifer L Perry,Marissa M Anderson,Sarah E Nelson,Marilyn E Carroll,

Adolescence and excessive intake of saccharin have each been previously associated with enhanced vulnerability to drug abuse. In the present study, we focused on the relationship between these two factors using male adolescent and adult rats selectively bred for high (HiS) and low (LoS) levels of saccharin intake. On postnatal day 25 (adolescents) or 150 (adults), rats were implanted with an intravenous catheter and trained to self-administer cocaine (0.4 mg/kg) using an autoshaping procedure that consisted of two 6-h sessions. In the first 6 h, rats were given non-contingent cocaine infusions at random intervals 10 times per hour, and during the second 6-h session, rats were allowed to self-administer cocaine under a fixed ratio 1 (FR 1) lever-response contingency. Acquisition was defined as a total of at least 250 infusions over 5 consecutive days, and rats were given 30 days to meet the acquisition criterion. Subsequently, saccharin phenotype scores were determined by comparing 24-h saccharin and water consumption in two-bottle tests to verify HiS/LoS status. Adolescent LoS rats had a faster rate of acquisition of cocaine self-administration than adult LoS rats; however, adolescent and adult HiS rats acquired at the same rate. Both HiS and LoS adolescents had significantly higher saccharin phenotype scores than HiS and LoS adults, respectively. Additionally, saccharin score was negatively correlated with the number of days to meet the acquisition criterion for cocaine self-administration, but this was mostly accounted for by the HiS adolescents. These results suggest that during adolescence, compared with adulthood, rats have both an increased avidity for sweets and vulnerability to initiate drug abuse.

Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake. Publishing Authors By Initials

JL Perry,MM Anderson,SE Nelson,ME Carroll,

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Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Physiology & behavior

VOLUME: 91

Page Numbers: 126-33

Journal Abbreviation:

ISSN: 0031-9384

DAY: 12

MONTH: 02

YEAR: 2007

Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 151504

Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake. Keywords Mesh Terms:

KEYWORDS: Taste

MESH TERMS: genetics

Chemical & Substance for Abstract: Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake. Information

Substance Name: Saccharin

Registry Number: 81-07-2

Grant and Affiliation Information for Acquisition of i.v. cocaine self-administration in adolescent and adult male rats selectively bred for high and low saccharin intake.

AFFILIATION: University of Kentucky, BBSRB, Room 248F, 741 S. Limestone, Lexington, KY 40536-0509, United States. Jennifer.Perry@uky.edu

Country: United States

AGENCY: United States NIDA

GRANT: R31 DA020237

ACRONYM: DA

MEDLINETA: Physiol Behav

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