Acquired cutis laxa concomitant with nephrotic syndrome.

Acquired cutis laxa concomitant with nephrotic syndrome. Research Abstract Details 

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Acquired cutis laxa concomitant with nephrotic syndrome. Abstract Text:

A 41-year-old woman developed laxity and wrinkling of the skin. This process spread slowly to involve the skin of almost the entire body, without any previous inflammatory skin disorder. The skin of her face, neck, and trunk hung in loose folds, leading to a prematurely aged appearance. One year later she noticed edema on her face and legs. Laboratory studies disclosed low C3 and CH50 serum levels and proteinuria. Skin biopsy specimens revealed extensive loss and fragmentation of dermal elastic fibers. A renal biopsy specimen showed membranoproliferative glomerulonephritis (type 2), and an immunofluorescent study disclosed C3 and IgG deposition in the mesangial matrix and along the glomerular basement membrane. We propose that, in this case, cutis laxa may be related to an abnormal immune response.

Acquired cutis laxa concomitant with nephrotic syndrome. Publishing Authors By Initials

For similar integumentary system: skin research abstracts see: integumentary system: skin research

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Acquired cutis laxa concomitant with nephrotic syndrome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 123

Page Numbers: 1211-6

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Sep

YEAR: 1987

Acquired cutis laxa concomitant with nephrotic syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Acquired cutis laxa concomitant with nephrotic syndrome. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Acquired cutis laxa concomitant with nephrotic syndrome. Information

Substance Name: Immunoglobulins

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Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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