Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs.

Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs. Research Abstract Details 

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Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs. Abstract Text:

Ken-ichi Watanabe,Shunta Inai,Alexander Hess,Olaf Michel,Toshiaki Yagi,

Loud acoustic stimulation is known to cause inner ear disturbance. We examined immunohistochemically the vestibule of 12 guinea pigs after acoustic stimulation. The animals were divided into two equal groups: a control group and an acoustic stimulation group. The temporal bones were fixed by means of a cardiac infusion of fixative and immunohistochemically stained for inducible nitric oxide synthase (iNOS). The temporal bones in the control group did not show any iNOS. In the acoustic stimulation group, immunoreactivity for iNOS was detected in the supporting cells and sensory cells of the sensory epithelium, in the dark cell areas and in the vestibular ganglion cells. These findings suggest that free radicals are involved in the pathogenesis of noise-induced inner ear damage. Furthermore, free radicals may cause vestibular damage, as is seen in noise-induced inner ear damage.

Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs. Publishing Authors By Initials

K Watanabe,S Inai,A Hess,O Michel,T Yagi,

For similar ear, inner: vestibule, labyrinth research abstracts see: ear, inner: vestibule, labyrinth research

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Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oto-laryngologica. Supplementum

VOLUME:

Page Numbers: 54-7

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ISSN: 0365-5237

DAY: 13

MONTH: Aug

YEAR: 2004

Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs. Keywords Mesh Terms:

KEYWORDS: Vestibule, Labyrinth

MESH TERMS: physiology

Chemical & Substance for Abstract: Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs. Information

Substance Name: Nitric Oxide Synthase

Registry Number: EC 1.14.13.39

Grant and Affiliation Information for Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs.

AFFILIATION: Department of Otorhinolaryngology, Nippon Medical School, Kawasaki, Kanagawa, Japan. bxp02646@nifty.ne.jp

Country: Norway

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MEDLINETA: Acta Otolaryngol Suppl

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