Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent.

Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent. Research Abstract Details 

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Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent. Abstract Text:

Andrea H Lo,Oliver D Kripfgans,Paul L Carson,Edward D Rothman,J Brian Fowlkes,

The use of superheated liquid perfluorocarbon droplets encased in albumin shells has been proposed as a minimally invasive alternative to current treatment of cancer by means of occlusion therapy. In response to an applied acoustic field, these droplets, which are small enough to pass through capillaries, vaporize into large gas bubbles that subsequently lodge in the vasculature. This technique, known as acoustic droplet vaporization (ADV) has been shown to successfully reduce blood flow in vivo, but for in situ conditions where attenuation is present, lower acoustic frequency and ADV threshold may be desirable. Thus, two methods to lower the ADV threshold at a lower 1.44 MHz were explored. The first part of this study investigated the role of pulse duration on ADV. The second part investigated the role of inertial cavitation (IC) external to a droplet by lowering the IC threshold in the host liquid with the presence of Definity contrast agent (CA). The threshold was found to be 5.5-5.9 MPa for short microsecond pulses and decreased for millisecond pulses (3.8-4.6 MPa). When CAs were present and long millisecond pulses were used, the ADV threshold decreased to values as low as 0.41 MPa.

Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent. Publishing Authors By Initials

AH Lo,OD Kripfgans,PL Carson,ED Rothman,JB Fowlkes,

For similar pharmaceutical preparations: solutions research abstracts see: pharmaceutical preparations: solutions research

PUBMED ID PMID:

MEDLINE DATE:

Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: IEEE transactions on ultrasonics, ferroelectrics,

VOLUME: 54

Page Numbers: 933-46

Journal Abbreviation:

ISSN: 0885-3010

DAY: 3

MONTH: May

YEAR: 2007

Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9882735

Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent. Keywords Mesh Terms:

KEYWORDS: Solutions

MESH TERMS: radiation effects

Chemical & Substance for Abstract: Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent. Information

Substance Name: Solutions

Registry Number: 0

Grant and Affiliation Information for Acoustic droplet vaporization threshold: effects of pulse duration and contrast agent.

AFFILIATION: University of Michigan, Department of Biomedical Engineering and Radiology, Ann Arbor, MI, USA. ahlo@umich.edu

Country: United States

AGENCY: United States NIBIB

GRANT: 5R01 EB00281-09

ACRONYM: EB

MEDLINETA: IEEE Trans Ultrason Ferroelect

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