Acidic glycosphingolipids of human amnion.

Acidic glycosphingolipids of human amnion. Research Abstract Details 

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Acidic glycosphingolipids of human amnion. Abstract Text:

K Asano,M Suzuki,S Handa,M Oshima,

Six major acidic glycosphingolipids were isolated from human amnion using DEAE Sephadex A-25 and silica beads column chromatography. The structures of these glycosphingolipids were determined by methylation analysis, TLC immunostaining and/or negative ion FAB-MS, and were concluded to be II3 alpha NeuAcLacCer(GM3), IV3 alpha NeuAcnLc4-Cer (sialyl[alpha 2-3]paragloboside), IV6 alpha NeuAcnLc4Cer (sialyl[alpha 2-6]paragloboside), IV3 alpha NeuAcIII4 alpha FucLc4Cer (sialyl Lea), VI3 alpha NeuAcnLc6Cer (i-ganglioside) and II3 alpha (NeuAc alpha 2----8NeuAc)LacCer (GD3). In addition, several minor glycosphingolipids were detected with specific monoclonal antibodies, including glycolipids with NeuAc alpha 2-3Gal beta 1-4GlcNAc-beta 1- or NeuAc alpha 2-6Gal beta 1-4GlcNAc beta 1- determinant. Our results show that the glycosphingolipids of human amnion are characterized by having mainly type II chain analogues and onco-fetal antigens.

Acidic glycosphingolipids of human amnion. Publishing Authors By Initials

K Asano,M Suzuki,S Handa,M Oshima,

For similar reproductive and urinary physiology: reproduction: pregnancy research abstracts see: reproductive and urinary physiology: reproduction: pregnancy research

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Acidic glycosphingolipids of human amnion. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 109

Page Numbers: 106-12

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jan

YEAR: 1991

Acidic glycosphingolipids of human amnion. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Acidic glycosphingolipids of human amnion. Keywords Mesh Terms:

KEYWORDS: Pregnancy

MESH TERMS: isolation & purification

Chemical & Substance for Abstract: Acidic glycosphingolipids of human amnion. Information

Substance Name: oncofetal antigens

Registry Number: 0

Grant and Affiliation Information for Acidic glycosphingolipids of human amnion.

AFFILIATION: Division of Clinical Biochemistry, National Medical Center, Tokyo.

Country: JAPAN

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MEDLINETA: J Biochem

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