Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.

Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Research Abstract Details 

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Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Abstract Text:

Brahm H Segal,Bruce A Davidson,Alan D Hutson,Thomas A Russo,Bruce A Holm,Barbara Mullan,Michael Habitzruther,Steven M Holland,Paul R Knight,

Increased reactive oxidant intermediates (ROIs) from primed leukocytes have been implicated in the pathogenesis of acid aspiration lung injury. To evaluate the specific role of the phagocyte NADPH oxidase-derived ROIs in acid lung injury, the p47phox-/- knockout mouse model of chronic granulomatous disease was used. p47phox-/- mice developed a significantly greater alveolar neutrophilic leukocytosis compared with wild-type mice at all time points after acid injury, with the difference between genotypes being most marked at 48 h. In contrast, the p47phox-/- mice had a decreased number of macrophages in bronchoalveolar lavage (BAL) compared with wild-type at 48 h after acid or saline aspiration. Albumin concentration in BAL reflecting capillary leak was also greater in p47phox-/- compared with wild-type mice. BAL concentrations of proinflammatory cytokines and chemokines were greater in p47phox-/- compared with wild-type mice. These findings suggest that NADPH oxidase, directly or indirectly, plays a role in attenuating the acute neutrophilic response after acid lung injury. We speculate that this downmodulating effect may be mediated by promoting the transition from production of cytokines and chemokines involved in neutrophilic infiltration to a less injurious, chronic inflammatory response.

Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Publishing Authors By Initials

BH Segal,BA Davidson,AD Hutson,TA Russo,BA Holm,B Mullan,M Habitzruther,SM Holland,PR Knight,

For similar respiratory tract diseases: lung diseases: pneumonia research abstracts see: respiratory tract diseases: lung diseases: pneumonia research

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Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Lung cellular and

VOLUME: 292

Page Numbers: L760-8

Journal Abbreviation: Am. J. Physiol. Lung Cell Mol.

ISSN: 1040-0605

DAY: 17

MONTH: 11

YEAR: 2006

Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Information

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LANGUAGE: eng

NlmUniqueID: 100901229

Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Keywords Mesh Terms:

KEYWORDS: Pneumonia

MESH TERMS: pathology

Chemical & Substance for Abstract: Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Information

Substance Name: neutrophil cytosolic factor 1

Registry Number: EC 1.6.3.1

Grant and Affiliation Information for Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.

AFFILIATION: Department of Medicine, Roswell Park Cancer Institute, University at Buffalo-State University of New York, Buffalo, NY 14214-3013, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-48889

ACRONYM: HL

MEDLINETA: Am J Physiol Lung Cell Mol Phy

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