Achievements and future problems with component surgery of the cornea.

Achievements and future problems with component surgery of the cornea. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Achievements and future problems with component surgery of the cornea. Abstract Text:

Tetsuya Kawakita,Motoko Kawashima,Yoshiyuki Satake,Seika Den,Machiko Tomita,Jun Shimazaki,Tetsuya Kawakita,Motoko Kawashima,Yoshiyuki Satake,Seika Den,Machiko Tomita,Jun Shimazaki,

Penetrating keratoplasty (PKP) has long been the standard procedure for treating corneal opacification. Recent advances in corneal surgery have enabled us to perform component surgery of the cornea, replacing necessary cells and tissue only instead of changing the entire layer of the cornea. Corneal components can be transplanted as lamellar sections of donor cornea or as ex vivo expanded cell sheets with or without biologic carriers. Transplantation of cultivated epithelial sheets expanded from limbal epithelium or oral mucosal epithelium, deep lamellar keratoplasty (DLKP), and deep lamellar endothelial keratoplasty (DLEK) are already in clinical application. These surgical techniques have the advantage of reducing surgical trauma, risk of immunologic rejection, and refractive error. Furthermore, severe ocular surface diseases caused by total limbal stem-cell deficiency including Stevens-Johnson syndrome can be treated by such epithelial sheet transplantation. Although limbal transplantation (LT) has also been applied for such cases, epithelial sheet transplantation has the advantage of covering the corneal surface during surgery, which may reduce postoperative inflammation. However, the success rate of clinical outcome is still not sufficient. We review the surgical technique of component surgery and compare the clinical results including visual acuity, clarity of the cornea, and neovascularization between LT and epithelial sheet transplantation and among PKP, DLKP, and DLEK in our institute. Further refinements in surgical and biologic technology may take the limits of corneal regenerative medicine to new horizons.

Achievements and future problems with component surgery of the cornea. Publishing Authors By Initials

T Kawakita,M Kawashima,Y Satake,S Den,M Tomita,J Shimazaki,T Kawakita,M Kawashima,Y Satake,S Den,M Tomita,J Shimazaki,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Achievements and future problems with component surgery of the cornea. Journal Published:

PUBLICATION TYPE: Review

Journal: Cornea

VOLUME: 26

Page Numbers: S59-64

Journal Abbreviation: Cornea

ISSN: 0277-3740

DAY: 20

MONTH: Oct

YEAR: 2007

Achievements and future problems with component surgery of the cornea. Information

Number of References: 21

LANGUAGE: eng

NlmUniqueID: 8216186

Achievements and future problems with component surgery of the cornea. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Achievements and future problems with component surgery of the cornea. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Achievements and future problems with component surgery of the cornea.

AFFILIATION: Department of Ophthalmology, Tokyo Dental College, 5-11-13 Sugano, Ichikawa, Chiba, Japan. kawakitat@tdc.ac.jp

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cornea

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Achievements and future problems with component surgery of the cornea Related Publications

• Achievements and future problems with component surgery of the cornea.
• Amniotic membrane transplantation for wound dehiscence after deep lamellar keratoplasty: a case report.
• Barrier function and cytologic features of the ocular surface epithelium after autologous cultivated oral mucosal epithelial transplantation.
• Blue light-induced autophosphorylation of phototropin is a primary step for signaling.
• Hyperleukocytosis in patients with leukemic follicular lymphoma.
• Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis.
• In vitro effects of bovine lactoferrin on autoaggregation ability and surface hydrophobicity of bifidobacteria.
• Insects from the grazing food web favoured the evolutionary habitat shift to bright environments in araneoid spiders.
• Interrelationship between plasma ionized calcium, plasma noradrenaline (NA) and pressor response to infused NA in patients with essential hypertension.
• Metastasis suppressor genes for prostate cancer.
• Nonsurgical management of patients with blunt hepatic injury: efficacy of transcatheter arterial embolization.
• Nonsurgical management of patients with blunt splenic injury: efficacy of transcatheter arterial embolization.
• Outcome of patients with hormone-refractory prostate cancer: prognostic significance of prostate-specific antigen-doubling time and nadir prostate-specific antigen.
• Physiological properties of projection neurons in the monkey striatum to the globus pallidus.
• Postkeratoplasty atopic sclerokeratitis in keratoconus patients.
• Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers.
• Prop-type damping device.
• Protein phosphorylation and binding of a 14-3-3 protein in Vicia guard cells in response to ABA.
• SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia.
• Sensory afferent properties of immobilised or inflamed rat knees during continuous passive movement.
• Thyroid storm after blunt thyroid injury: a case report.
• [A case of caffeine poisoning, survived by percutaneous cardio-pulmonary support]
• [Focal point in the evaluation of nursing fees. A discussion]
• [Multiple coronary aneurysm resulting in myocardial infarction in a young man - successful surgical treatment using a bypass graft]
• [Nursing report: nursing students; attitudes toward nursing at the time of graduation from a 3-year nursing college]
• [Personification; a psychopathological study of the feeling of nature.]
• [Radiation induced osteosarcoma of the chest wall]
• [Simultaneous repair for funnel chest and intracardiac lesions in two pediatric patients]
• [The role of stem cell transplantation for multiple myeloma]
• [Ventricular volume characteristics and function in patients with single ventricle]