Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal.

Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal. Research Abstract Details 

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Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal. Abstract Text:

Jeremy P Walker,Sanford A Asher,

We developed a polymerized crystalline colloidal array (PCCA) photonic crystal sensing material that senses the organophosphorus compound parathion at ultratrace concentrations in aqueous solutions. A periodic array of colloidal particles is embedded in a hydrogel network with a lattice spacing such that it Bragg diffracts visible light. The molecular recognition agent for the sensor is the enzyme acetylcholinesterase (AChE), which binds organophosphorus compounds irreversibly, creating an anionic phosphonyl species. This charged species creates a Donnan potential, which swells the hydrogel network, which increases the embedded particle array lattice spacing and causes a red-shift in the wavelength of light diffracted. The magnitude of the diffraction red-shift is proportional to the amount of bound parathion. These AChE-PCCAs act as dosimeters for parathion since it irreversibly binds. Parathion concentrations as low as 4.26 fM are easily detected.

Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal. Publishing Authors By Initials

JP Walker,SA Asher,

For similar macromolecular substances: polymers research abstracts see: macromolecular substances: polymers research

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Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Analytical chemistry

VOLUME: 77

Page Numbers: 1596-600

Journal Abbreviation: Anal. Chem.

ISSN: 0003-2700

DAY: 15

MONTH: Mar

YEAR: 2005

Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370536

Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal. Keywords Mesh Terms:

KEYWORDS: Polymers

MESH TERMS: analysis

Chemical & Substance for Abstract: Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal. Information

Substance Name: Acetylcholinesterase

Registry Number: EC 3.1.1.7

Grant and Affiliation Information for Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal.

AFFILIATION: Department of Chemistry, Chevron Science Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

Country: United States

AGENCY: United States NCI

GRANT: N01-CO-17016-32

ACRONYM: CO

MEDLINETA: Anal Chem

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