Acetylcholine and delirium.

Acetylcholine and delirium. Research Abstract Details 

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Acetylcholine and delirium. Abstract Text:

L E Tune,S Egeli,

The neurotransmitter acetylcholine has been implicated in animal and human studies of delirium. This chapter will briefly review the clinical studies focussing on measurement of serum levels of anticholinergic activity in delirious states. Three approaches have been taken. First, to identify medications currently prescribed that have subtle anticholinergic effects. The current 'list' includes 48 commonly prescribed medications. Second, to associate serum anticholinergic activity with delirium in various clinical states including postcardiotomy delirium, postelectroconvulsive delirium, delirious elderly medical inpatients, and nursing home patients. Third, to intervene in patients with elevated anticholinergic activity by reducing known anticholinergics and correlating this reduction with clinical measures of cognition and delirium. Our most recent data investigates the impact of anticholinergics on demented patients. Rates of delirium were significantly higher in patients receiving larger numbers of anticholinergics.

Acetylcholine and delirium. Publishing Authors By Initials

LE Tune,S Egeli,

For similar therapeutics: drug therapy: polypharmacy research abstracts see: therapeutics: drug therapy: polypharmacy research

PUBMED ID PMID:

MEDLINE DATE: 1999 Sep-Oct

Acetylcholine and delirium. Journal Published:

PUBLICATION TYPE: Review

Journal: Dementia and geriatric cognitive disorders

VOLUME: 10

Page Numbers: 342-4

Journal Abbreviation: Dement Geriatr Cogn Disord

ISSN: 1420-8008

DAY: 24

MONTH: 03

YEAR: 2008

Acetylcholine and delirium. Information

Number of References: 9

LANGUAGE: eng

NlmUniqueID: 9705200

Acetylcholine and delirium. Keywords Mesh Terms:

KEYWORDS: Polypharmacy

MESH TERMS: blood

Chemical & Substance for Abstract: Acetylcholine and delirium. Information

Substance Name: Acetylcholine

Registry Number: 51-84-3

Grant and Affiliation Information for Acetylcholine and delirium.

AFFILIATION: Division of Geriatric Psychiatry, Wesley Woods Center at Emory University, Atlanta, GA 30329, USA.

Country: SWITZERLAND

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MEDLINETA: Dement Geriatr Cogn Disord

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