Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination.

Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination. Research Abstract Details 

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Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination. Abstract Text:

Karl P Nightingale,Matthias Baumann,Anton Eberharter,Adamantios Mamais,Peter B Becker,Joan Boyes,

Targeted chromatin remodelling is essential for many nuclear processes, including the regulation of V(D)J recombination. ATP-dependent nucleosome remodelling complexes are important players in this process whose activity must be tightly regulated. We show here that histone acetylation regulates nucleosome remodelling complex activity to boost RAG cutting during the initiation of V(D)J recombination. RAG cutting requires nucleosome mobilization from recombination signal sequences. Histone acetylation does not stimulate nucleosome mobilization per se by CHRAC, ACF or their catalytic subunit, ISWI. Instead, we find the more open structure of acetylated chromatin regulates the ability of nucleosome remodelling complexes to access their nucleosome templates. We also find that bromodomain/acetylated histone tail interactions can contribute to this targeting at limited concentrations of remodelling complex. We therefore propose that the changes in higher order chromatin structure associated with histone acetylation contribute to the correct targeting of nucleosome remodelling complexes and this is a novel way in which histone acetylation can modulate remodelling complex activity.

Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination. Publishing Authors By Initials

KP Nightingale,M Baumann,A Eberharter,A Mamais,PB Becker,J Boyes,

For similar genetic processes: recombination, genetic research abstracts see: genetic processes: recombination, genetic research

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Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nucleic acids research

VOLUME: 35

Page Numbers: 6311-21

Journal Abbreviation: Nucleic Acids Res.

ISSN: 1362-4962

DAY: 18

MONTH: 09

YEAR: 2007

Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination. Information

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LANGUAGE: eng

NlmUniqueID: 411011

Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination. Keywords Mesh Terms:

KEYWORDS: Recombination, Genetic

MESH TERMS: metabolism

Chemical & Substance for Abstract: Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination. Information

Substance Name: RAG-1 protein

Registry Number: 128559-51-3

Grant and Affiliation Information for Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination.

AFFILIATION: Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Country: England

AGENCY: United Kingdom Wellcome T

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MEDLINETA: Nucleic Acids Res

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