[Acellular porcine dermal matrix produced with different methods and an experimental study on its transplantation to skin wound.]

[Acellular porcine dermal matrix produced with different methods and an experimental study on its transplantation to skin wound.] Research Abstract Details 

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[Acellular porcine dermal matrix produced with different methods and an experimental study on its transplantation to skin wound.] Abstract Text:

Zhong-feng Ma,Jia-ke Chai,Hong-ming Yang,Qiang Liu,Ming-huo Xu,Hui-nan Yin,

OBJECTIVE: To observed the effect of healing quality of composite skin grafting consisting of acellular porcine dermal matrix combined with autologous split-thickness skin graft. METHODS: Porcine skin was treated with dispase II/triton X-100 or hyperosmotic saline/sodium-dodecyl-sulfate (SDS) respectively, and acellular porcine dermal matrix I (APDMI) and APDM II were obtained. Sixty-three Sprague-Dawley rats with full-thickness skin defects on the back were separately covered with APDMT + split-thickness autologous skin, or APDM II + split-thickness autologous skin. The quality of wound healing was observed, the rates of survival and contraction of the grafts were calculated, the tissue samples were harvested for histological examination, and compared with that of autologous split-thickness skin graft. RESULTS: The wound healing quality of composite skin I, and II was good. There was no significant difference in the rate of survival and contraction of the grafts between the two composite skin grafting groups. It was indicated by histological examination intact basal membrane. There was no significant difference in the survival rate between composite skin grafting groups and autologous split-thickness skin at the 6 th week after operation, but the contraction rates of the grafts in the composite skin groups were lower. CONCLUSION: Full-thickness skin defect can be healed by covering with acellular porcine dermal matrix produced by two methods combined with split-thickness autolograft, and it can help improve the quality of wound healing.

[Acellular porcine dermal matrix produced with different methods and an experimental study on its transplantation to skin wound.] Publishing Authors By Initials

ZF Ma,JK Chai,HM Yang,Q Liu,MH Xu,HN Yin,

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[Acellular porcine dermal matrix produced with different methods and an experimental study on its transplantation to skin wound.] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese cr

VOLUME: 17

Page Numbers: 92-4

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ISSN: 1003-0603

DAY: 8

MONTH: Feb

YEAR: 2005

[Acellular porcine dermal matrix produced with different methods and an experimental study on its transplantation to skin wound.] Information

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LANGUAGE: chi

NlmUniqueID: 9887521

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Grant and Affiliation Information for [Acellular porcine dermal matrix produced with different methods and an experimental study on its transplantation to skin wound.]

AFFILIATION: Department of Burns and Plastic Surgery, Burns Institute, 304th Clinical Department of General Hospital of PLA, Beijing 100037, China.

Country: China

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MEDLINETA: Zhongguo Wei Zhong Bing Ji Jiu

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