Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors.

Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors. Research Abstract Details 

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Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors. Abstract Text:

OBJECTIVE: This study was undertaken to evaluate the ability of preoperative endometrial sampling to accurately diagnose high-grade endometrial tumors. STUDY DESIGN: Three hundred sixty endometrial cancer patients had preoperative endometrial sampling and hysterectomy specimens that underwent pathologic review at a single institution from 1995 to 2005. The sensitivity of Pipelle and curettage to diagnose high-grade endometrial tumors (grade 3 endometrioid adenocarcinoma, serous carcinoma, carcinosarcoma, clear cell carcinoma) was determined. Agreement between preoperative and hysterectomy diagnoses was measured by the Kappa statistic. RESULTS: Sensitivity of Pipelle and curettage was 93.8% and 97% in patients with low-grade cancer and 99.2% and 100% in patients with high-grade cancer. Good agreement was observed between the preoperative and the hysterectomy histologic diagnoses (Kappa = 0.69), and between the preoperative and hysterectomy tumor grade (Kappa=0.78). CONCLUSION: Preoperative endometrial sampling with Pipelle or curettage is sensitive and accurate for the diagnosis of high-grade endometrial tumors, including tumors with nonendometrioid histology.

Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors. Publishing Authors By Initials

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

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Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of obstetrics and gynecology

VOLUME: 196

Page Numbers: 243.e1-5

Journal Abbreviation: Am. J. Obstet. Gynecol.

ISSN: 1097-6868

DAY: 3

MONTH: Mar

YEAR: 2007

Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors. Information

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LANGUAGE: eng

NlmUniqueID: 370476

Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: surgery

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Grant and Affiliation Information for Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors.

AFFILIATION: Department of Obstetrics and Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA. ghuang@montefiore.org

Country: United States

AGENCY: United States NCRR

GRANT: K12 RR017672

ACRONYM: RR

MEDLINETA: Am J Obstet Gynecol

REFSOURCE: Am J Obstet Gynecol. 2007 Mar;196(3):e1-

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