Accuracy of MRI for estimating residual tumor size after neoadjuvant chemotherapy in locally advanced breast cancer: relation to response patterns on MRI.

Accuracy of MRI for estimating residual tumor size after neoadjuvant chemotherapy in locally advanced breast cancer: relation to response patterns on MRI. Research Abstract Details 

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Accuracy of MRI for estimating residual tumor size after neoadjuvant chemotherapy in locally advanced breast cancer: relation to response patterns on MRI. Abstract Text:

Hyun Jung Kim,Young-Hyuck Im,Boo-Kyung Han,Nami Choi,Jeeyun Lee,Jung Han Kim,Yoon-La Choi,Jin-Seok Ahn,Seok-Jin Nam,Young Suk Park,Yeon Hyeon Choe,Young-Hyeh Ko,Jung-Hyun Yang,Hyun Jung Kim,Young-Hyuck Im,Boo-Kyung Han,Nami Choi,Jeeyun Lee,Jung Han Kim,Yoon-La Choi,Jin-Seok Ahn,Seok-Jin Nam,Young Suk Park,Yeon Hyeon Choe,Young-Hyeh Ko,Jung-Hyun Yang,

BACKGROUND: This study evaluated the accuracy of magnetic resonance imaging (MRI) for estimating residual tumor size after neoadjuvant chemotherapy in patients with locally advanced breast cancer and assessed whether the tumor pattern on MRI after chemotherapy influenced the accuracy of the MRI measurement of the residual tumor size. PATIENTS AND METHODS: Fifty patients who received neoadjuvant chemotherapy with doxorubicin and docetaxel for locally advanced breast cancer were evaluated with MRI before and after chemotherapy. We compared the residual tumor size measured by MRI with the pathologically determined size and investigated the influence of the residual tumor pattern on MRI (shrinkage, nest or rim, and mixed) and pathologic characteristics on the accuracy of the MRI measurement. RESULTS: The correlation coefficient between the residual tumor sizes determined by MRI and by pathology was 0.645. The MRI measurement agreed with the pathologically determined size in 36 patients (72%) and disagreed in 14 patients 928%), overestimating the size in 13 (26%) and underestimating the size in one (2%). disagreement appeared to be more frequent in the cases showing a nest or rim pattern than in those exhibiting a shrinkage pattern, although this was not statistically significant (p = 0.119). CONCLUSIONS: MRI is an accurate method for predicting the extent of residual tumor after neoadjuvant chemotherapy; however, it may overestimate the residual disease, especially in cases showing a nest or rim tumor pattern and in those having combined lesions with ductal carcinoma in situ or multiple scattered nodules after neoadjuvant chemotherapy.

Accuracy of MRI for estimating residual tumor size after neoadjuvant chemotherapy in locally advanced breast cancer: relation to response patterns on MRI. Publishing Authors By Initials

HJ Kim,YH Im,BK Han,N Choi,J Lee,JH Kim,YL Choi,JS Ahn,SJ Nam,YS Park,YH Choe,YH Ko,JH Yang,HJ Kim,YH Im,BK Han,N Choi,J Lee,JH Kim,YL Choi,JS Ahn,SJ Nam,YS Park,YH Choe,YH Ko,JH Yang,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Accuracy of MRI for estimating residual tumor size after neoadjuvant chemotherapy in locally advanced breast cancer: relation to response patterns on MRI. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oncologica (Stockholm, Sweden)

VOLUME: 46

Page Numbers: 996-1003

Journal Abbreviation:

ISSN: 0284-186X

DAY: 3

MONTH: 04

YEAR: 2007

Accuracy of MRI for estimating residual tumor size after neoadjuvant chemotherapy in locally advanced breast cancer: relation to response patterns on MRI. Information

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LANGUAGE: eng

NlmUniqueID: 8709065

Accuracy of MRI for estimating residual tumor size after neoadjuvant chemotherapy in locally advanced breast cancer: relation to response patterns on MRI. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Accuracy of MRI for estimating residual tumor size after neoadjuvant chemotherapy in locally advanced breast cancer: relation to response patterns on MRI. Information

Substance Name: Doxorubicin

Registry Number: 23214-92-8

Grant and Affiliation Information for Accuracy of MRI for estimating residual tumor size after neoadjuvant chemotherapy in locally advanced breast cancer: relation to response patterns on MRI.

AFFILIATION: Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Country: Norway

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MEDLINETA: Acta Oncol

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