Accuracy of CT prediction of poor prognostic features in colonic cancer.

Accuracy of CT prediction of poor prognostic features in colonic cancer. Research Abstract Details 

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Accuracy of CT prediction of poor prognostic features in colonic cancer. Abstract Text:

S Burton,G Brown,N Bees,A Norman,O Biedrzycki,A Arnaout,A M Abulafi,R I Swift,S Burton,G Brown,N Bees,A Norman,O Biedrzycki,A Arnaout,A M Abulafi,R I Swift,S Burton,G Brown,N Bees,A Norman,O Biedrzycki,A Arnaout,A M Abulafi,R I Swift,

Whilst imaging of poor prognostic features in rectal cancers has assisted pre-operative treatment stratification, such features have yet to be evaluated in colonic cancers. This study aims to develop criteria for identifying poor prognostic features in colonic tumours and assess the accuracy of CT prediction against histopathology. Criteria were developed for predicting T-stage and N-stage, the presence of extramural vascular invasion and involvement of the retroperitoneal surgical margin (RSM). These criteria were tested on 33 patients with colonic cancer who underwent pre-operative high-resolution CT of their tumour. Two radiologists (Obs 1 and Obs 2) identified independently these poor prognostic features and the results were compared with the final histopathological results. Histological agreement and interobserver variation were calculated using the kappa test. Accuracy of CT prediction of tumour extension beyond muscularis propria was 82% (Obs 1) and 70% (Obs 2). Correct prediction of RSM involvement was 76% (95% confidence interval (CI): 57.8-88.9%) and 79% (95%CI: 61.1-91%) for Obs1 and Obs 2, respectively, with significant agreement between observers (kappa = 0.455, p = 0.050). Prognosis was correctly predicted using CT in 82% (95%CI: 61.5-81.2%) (Obs1) and 85% (95%CI: 68.1-94.9%) (Obs2) with moderate agreement (kappa = 0.459, kappa = 0.527, respectively) with histology. In conclusion, CT has potential as the imaging modality of choice in the pre-operative prediction of poor prognostic features in colonic cancers and could play a role in future treatment stratification.

Accuracy of CT prediction of poor prognostic features in colonic cancer. Publishing Authors By Initials

S Burton,G Brown,N Bees,A Norman,O Biedrzycki,A Arnaout,AM Abulafi,RI Swift,S Burton,G Brown,N Bees,A Norman,O Biedrzycki,A Arnaout,AM Abulafi,RI Swift,S Burton,G Brown,N Bees,A Norman,O Biedrzycki,A Arnaout,AM Abulafi,RI Swift,

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Accuracy of CT prediction of poor prognostic features in colonic cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The British journal of radiology

VOLUME: 81

Page Numbers: 10-9

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ISSN: 1748-880X

DAY: 29

MONTH: 10

YEAR: 2007

Accuracy of CT prediction of poor prognostic features in colonic cancer. Information

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LANGUAGE: eng

NlmUniqueID: 373125

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Grant and Affiliation Information for Accuracy of CT prediction of poor prognostic features in colonic cancer.

AFFILIATION: Departments of Colorectal Surgery, Radiology and Histopathology, Mayday University Hospital, London Road, Croydon, CR7 7YE.

Country: England

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MEDLINETA: Br J Radiol

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