Accuracy of 64-slice CT angiography for the detection of functionally relevant coronary stenoses as assessed with myocardial perfusion SPECT.

Accuracy of 64-slice CT angiography for the detection of functionally relevant coronary stenoses as assessed with myocardial perfusion SPECT. Research Abstract Details 

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Accuracy of 64-slice CT angiography for the detection of functionally relevant coronary stenoses as assessed with myocardial perfusion SPECT. Abstract Text:

Oliver Gaemperli,Tiziano Schepis,Pascal Koepfli,Ines Valenta,Jan Soyka,Sebastian Leschka,Lotus Desbiolles,Lars Husmann,Hatem Alkadhi,Philipp A Kaufmann,Oliver Gaemperli,Tiziano Schepis,Pascal Koepfli,Ines Valenta,Jan Soyka,Sebastian Leschka,Lotus Desbiolles,Lars Husmann,Hatem Alkadhi,Philipp A Kaufmann,

PURPOSE: CT angiography (CTA) offers a valuable alternative for the diagnosis of CAD but its value in the detection of functionally relevant coronary stenoses remains uncertain. We prospectively compared the accuracy of 64-slice CTA with that of myocardial perfusion imaging (MPI) using (99m)Tc-tetrofosmin-SPECT as the gold standard for the detection of functionally relevant coronary artery disease (CAD). METHODS: MPI and 64-slice CT were performed in 100 consecutive patients. CTA lesions were analysed quantitatively and area stenoses > or =50% and > or =75% were compared with the MPI findings. RESULTS: In 23 patients, MPI perfusion defects were found (12 reversible, 13 fixed). A total of 399 coronary arteries and 1,386 segments was analysed. Eighty-four segments (6.1%) in 23 coronary arteries (5.8%) of nine patients (9.0%) were excluded owing to insufficient image quality. In the remaining 1,302 segments, quantitative CTA revealed stenoses > or =50% in 57 of 376 coronary arteries (15.2%) and stenoses > or =75% in 32 (8.5%) coronary arteries. Using a cut-off at > or =75% area stenosis, CTA yielded the following sensitivity, specificity, negative (NPV) and positive predictive value (PPV), and accuracy for the detection of any (fixed and reversible) MPI defect: by patient, 75%, 90%, 93%, 68% and 87%, respectively; by artery, 76%, 95%, 99%, 50% and 94%, respectively. CONCLUSION: Sixty-four-slice CTA is a reliable tool to rule out functionally relevant CAD in a non-selected population with an intermediate pretest likelihood of disease. However, an abnormal CTA is a poor predictor of ischaemia.

Accuracy of 64-slice CT angiography for the detection of functionally relevant coronary stenoses as assessed with myocardial perfusion SPECT. Publishing Authors By Initials

O Gaemperli,T Schepis,P Koepfli,I Valenta,J Soyka,S Leschka,L Desbiolles,L Husmann,H Alkadhi,PA Kaufmann,O Gaemperli,T Schepis,P Koepfli,I Valenta,J Soyka,S Leschka,L Desbiolles,L Husmann,H Alkadhi,PA Kaufmann,

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Accuracy of 64-slice CT angiography for the detection of functionally relevant coronary stenoses as assessed with myocardial perfusion SPECT. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of nuclear medicine and molecular

VOLUME: 34

Page Numbers: 1162-71

Journal Abbreviation: Eur. J. Nucl. Med. Mol. Imagin

ISSN: 1619-7070

DAY: 12

MONTH: 01

YEAR: 2007

Accuracy of 64-slice CT angiography for the detection of functionally relevant coronary stenoses as assessed with myocardial perfusion SPECT. Information

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LANGUAGE: eng

NlmUniqueID: 101140988

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AFFILIATION: Nuclear Cardiology, Cardiovascular Center, University Hospital Zurich NUK C 40, Raemistrasse 100, 8091 Zurich, Switzerland.

Country: Germany

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MEDLINETA: Eur J Nucl Med Mol Imaging

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