Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats.

Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats. Research Abstract Details 

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Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats. Abstract Text:

E J van Hoogdalem,C D Heijligers-Feijen,J C Verhoef,A G de Boer,D D Breimer,

The bile salt derivative sodium tauro-24,25-dihydrofusidate (STDHF) has been reported to promote nasal absorption of insulin. In the present study the effect of STDHF on rectal insulin absorption was investigated in rats. At concentrations of 1 and 4% (w/v) it enhanced insulin bioavailability from 0.2 +/- 0.2 (control) to 4.2 +/- 3.2 and 6.7 +/- 2.1%, respectively, as assessed by radioimmunoassay. Insulin preparations with STDHF reduced blood glucose concentrations considerably in a concentration-dependent way. Coadministration of STDHF with Na2EDTA (0.25%, w/v) tended to increase further insulin bioavailability and hypoglycemic response. Varying the site of rectal administration did not influence these parameters.

Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats. Publishing Authors By Initials

EJ van Hoogdalem,CD Heijligers-Feijen,JC Verhoef,AG de Boer,DD Breimer,

For similar chemical and pharmacologic phenomena: stimulation, chemical research abstracts see: chemical and pharmacologic phenomena: stimulation, chemical research

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Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmaceutical research

VOLUME: 7

Page Numbers: 180-3

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 22

MONTH: Feb

YEAR: 1990

Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats. Information

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LANGUAGE: eng

NlmUniqueID: 8406521

Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats. Keywords Mesh Terms:

KEYWORDS: Stimulation, Chemical

MESH TERMS: drug effects

Chemical & Substance for Abstract: Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats. Information

Substance Name: Fusidic Acid

Registry Number: 6990-06-3

Grant and Affiliation Information for Absorption enhancement of rectally infused insulin by sodium tauro-24,25-dihydrofusidate (STDHF) in rats.

AFFILIATION: Division of Pharmacology, Sylvius Laboratories, State University of Leiden, The Netherlands.

Country: UNITED STATES

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MEDLINETA: Pharm Res

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