Absorbable collagen sponge combined with recombinant human basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve.

Absorbable collagen sponge combined with recombinant human basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve. Research Abstract Details 

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Absorbable collagen sponge combined with recombinant human basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve. Abstract Text:

Cheng-Can Yao,Ping Yao,Hao Wu,Zhen-Gang Zha,Cheng-Can Yao,Ping Yao,Hao Wu,Zhen-Gang Zha,

Recombinant human basic fibroblast growth factor (rhbFGF) is a peptide with many bioactivities such as promoting proliferation and migration of various cells. It plays an important role in neuroprotection and enhancement of nerve regeneration. Due to its short half-life in the body, local administration by injection is limited. To prolong the bioactivity of rhbFGF and to enhance its biological effects, absorbable collagen sponge was used as matrixes and carriers for controlled release of rhbFGF. The effects of rhbFGF soaked into an absorbable collagen sponge (rhbFGF/ACS) for the repair of rat sciatic nerve injury were evaluated. The functional, electrophysiological and histological examinations demonstrate the treatment with rhbFGF/ACS can enhance rat sciatic nerve repair, and its effectiveness is better than free rhbFGF alone. It is concluded the rhbFGF/ACS is a promising biomaterial to improve the repair and regeneration of sciatic nerve injury.

Absorbable collagen sponge combined with recombinant human basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve. Publishing Authors By Initials

CC Yao,P Yao,H Wu,ZG Zha,CC Yao,P Yao,H Wu,ZG Zha,

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Absorbable collagen sponge combined with recombinant human basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of materials science. Materials in medicin

VOLUME: 18

Page Numbers: 1969-72

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ISSN: 0957-4530

DAY: 7

MONTH: 06

YEAR: 2007

Absorbable collagen sponge combined with recombinant human basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve. Information

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LANGUAGE: eng

NlmUniqueID: 9013087

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Grant and Affiliation Information for Absorbable collagen sponge combined with recombinant human basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve.

AFFILIATION: College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.

Country: United States

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MEDLINETA: J Mater Sci Mater Med

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