Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1.

Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1. Research Abstract Details 

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Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1. Abstract Text:

Gareth R Howell,Richard T Libby,Jeffrey K Marchant,Lawriston A Wilson,Ioan M Cosma,Richard S Smith,Michael G Anderson,Simon W M John,

BACKGROUND: The glaucomas are a common but incompletely understood group of diseases. DBA/2J mice develop a pigment liberating iris disease that ultimately causes elevated intraocular pressure (IOP) and glaucoma. We have shown previously that mutations in two genes, Gpnmb and Tyrp1, initiate the iris disease. However, mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear. RESULTS: Here we present new mouse strains with Gpnmb and/or Tyrp1 genes of normal function and with a DBA/2J genetic background. These strains do not develop elevated IOP or glaucoma with age. CONCLUSION: These strains provide much needed controls for studying pathogenic mechanisms of glaucoma using DBA/2J mice. Given the involvement of Gpnmb and/or Tyrp1 in areas such as immunology and tumor development and progression, these strains are also important in other research fields.

Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1. Publishing Authors By Initials

GR Howell,RT Libby,JK Marchant,LA Wilson,IM Cosma,RS Smith,MG Anderson,SW John,

For similar enzymes and coenzymes: enzymes: oxidoreductases research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases research

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Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: BMC genetics

VOLUME: 8

Page Numbers: 45

Journal Abbreviation: BMC Genet.

ISSN: 1471-2156

DAY: 3

MONTH: 07

YEAR: 2007

Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1. Information

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LANGUAGE: eng

NlmUniqueID: 100966978

Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1. Keywords Mesh Terms:

KEYWORDS: Oxidoreductases

MESH TERMS: genetics

Chemical & Substance for Abstract: Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1. Information

Substance Name: Tyrp1 protein, mouse

Registry Number: EC 1.14.18.-

Grant and Affiliation Information for Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1.

AFFILIATION: The Jackson Laboratory, Bar Harbor, Maine, USA. gareth.howell@jax.org <gareth.howell@jax.org>

Country: England

AGENCY: United States NEI

GRANT: F32EY07015

ACRONYM: EY

MEDLINETA: BMC Genet

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