Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia.

Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia. Research Abstract Details 

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Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia. Abstract Text:

Felix Stonek,Erich Hafner,Martin Metzenbauer,Schuchter Katharina,Ingrid ,Christian Schneeberger,Harald Zeisler,Peter Husslein,Karl Philipp,Felix Stonek,Erich Hafner,Martin Metzenbauer,Schuchter Katharina,Ingrid ,Christian Schneeberger,Harald Zeisler,Peter Husslein,Karl Philipp,

OBJECTIVE: TNF-alpha G308A, IL-6 G174C and IL-10 G1082A polymorphisms have recently been associated with preeclampsia (PE). The aim of this study was to clarify whether the occurrence of TNF-alpha, IL-6 and IL-10 polymorphisms is increased in women of our population with PE in a previous pregnancy. METHODS: A retrospective, controlled, open, multicenter study was carried out in 107 women with a history of PE and 107 women with uncomplicated pregnancies. Smears from buccal gingival cells were analyzed for the polymorphisms of TNF-alpha, IL-6 and IL-10 by hybridization on microarrays. Statistical significance was calculated by the chi-quadrant test. RESULTS: Heterozygocity for the gene polymorphisms did not occur more often in preeclamptic women compared with controls (TNF-alpha: 29.0% versus 24.3%, p>0.05; IL-6: 46.7% versus 51.4%, p>0.05; or IL-10: 49.5% in each). Moreover, there was no significant difference between preeclamptics and controls with regard to homozygocity for TNF alpha (1.9% versus 3.7%, p>0.05); IL-6 (17.8% versus 13.1%, p>0.05); and IL-10 (30.8% versus 32.7%, p>0.05). CONCLUSION: In contrast to the findings of some other investigators, gene polymorphisms do not seem to be important in our population for development of PE.

Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia. Publishing Authors By Initials

F Stonek,E Hafner,M Metzenbauer,S Katharina,I ,C Schneeberger,H Zeisler,P Husslein,K Philipp,F Stonek,E Hafner,M Metzenbauer,S Katharina,I ,C Schneeberger,H Zeisler,P Husslein,K Philipp,

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Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of reproductive immunology

VOLUME: 77

Page Numbers: 85-90

Journal Abbreviation: J. Reprod. Immunol.

ISSN: 0165-0378

DAY: 4

MONTH: 06

YEAR: 2007

Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia. Information

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LANGUAGE: eng

NlmUniqueID: 8001906

Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia. Keywords Mesh Terms:

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Grant and Affiliation Information for Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia.

AFFILIATION: Department of Obstetrics and Gynecology, Danube Hospital/SMZ-Ost, Langobardenstrasse 122, 1220 Vienna, Austria.

Country: Ireland

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MEDLINETA: J Reprod Immunol

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