Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections.

Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections. Research Abstract Details 

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Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections. Abstract Text:

Heike Unsoeld,Katja Mueller,Ulrike Schleicher,Christian Bogdan, Zwirner,David Voehringer,Hanspeter Pircher,Heike Unsoeld,Katja Mueller,Ulrike Schleicher,Christian Bogdan, Zwirner,David Voehringer,Hanspeter Pircher,Heike Unsoeld,Katja Mueller,Ulrike Schleicher,Christian Bogdan,Jörg Zwirner,David Voehringer,Hanspeter Pircher,

The CC chemokine receptor 7 (CCR7) and its two ligands, CCL21 and CCL19, play an important role in migration of immune cells to lymphoid tissue. To analyze the function of CCR7 in T cell immunity to infectious agents in vivo, transgenic (tg) mice expressing CCL21 in an ubiquitous fashion were generated. These mice contained high amounts of CCL21 in the serum ( approximately 0.3 mug/ml that resulted in CCR7 down-regulation and in a strongly impaired migration of T cells toward CCL21 in vitro. Lymph nodes in CCL21-tg mice were reduced in size but with intact microanatomy and normal distribution of T and B cells. CCL21-tg mice showed a significantly decreased CD8 T cell response to lymphocytic choriomeningitis virus after footpad infection, whereas the response after systemic infection was not altered. Likewise, the CD4 T cell response to footpad infection with Leishmania major was considerably lowered and CCL21-tg mice failed to clear parasites from infected skin. Taken together, these data demonstrate the importance of CCR7 in mediating T cell immunity to viral and parasitic pathogens after local infection.

Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections. Publishing Authors By Initials

H Unsoeld,K Mueller,U Schleicher,C Bogdan,J Zwirner,D Voehringer,H Pircher,H Unsoeld,K Mueller,U Schleicher,C Bogdan,J Zwirner,D Voehringer,H Pircher,H Unsoeld,K Mueller,U Schleicher,C Bogdan,J Zwirner,D Voehringer,H Pircher,

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Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International immunology

VOLUME: 19

Page Numbers: 1281-9

Journal Abbreviation: Int. Immunol.

ISSN: 0953-8178

DAY: 3

MONTH: 10

YEAR: 2007

Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections. Information

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LANGUAGE: eng

NlmUniqueID: 8916182

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Grant and Affiliation Information for Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections.

AFFILIATION: Department of Immunology, Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.

Country: England

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MEDLINETA: Int Immunol

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