Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division.

Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division. Research Abstract Details 

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Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division. Abstract Text:

Sharron A Stubbs,Jaroslav Stark,Stephen M Dilworth,Stephen Franks,Kate Hardy,Sharron A Stubbs,Jaroslav Stark,Stephen M Dilworth,Stephen Franks,Kate Hardy,Sharron A Stubbs,Jaroslav Stark,Stephen M Dilworth,Stephen Franks,Kate Hardy,

Context: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, but its etiology remains obscure. Recent data suggest that an intrinsic abnormality of early follicle development in the ovary is key to the pathogenesis of PCOS. We have recently found that in PCOS the proportion of primordial follicles is decreased with a reciprocal increase in the proportion of primary follicles. Objective: Our aim was to examine whether the accelerated transition of follicles from primordial to primary stages in polycystic ovaries (PCO) is due to increased granulosa cell (GC) division. Design: This study is a comparison of expression of minichromosome maintenance protein 2 (MCM2) (present in the nuclei of cells that are licensed to divide) in archive tissue from normal and PCO. Setting: This is a laboratory-based study. Patients: There were 16 women with regular cycles (six with normal and 10 with PCO) and five anovulatory women with PCO, classified histologically, with reference to menstrual history and ultrasound. Main Outcome Measures: The presence of MCM2 expression in the GCs of 1371 follicles was determined. Results: GC proliferation was increased in anovulatory PCO compared with both normal and ovulatory PCO, with an increased proportion of preantral follicles with MCM2-positive GCs (P

Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division. Publishing Authors By Initials

SA Stubbs,J Stark,SM Dilworth,S Franks,K Hardy,SA Stubbs,J Stark,SM Dilworth,S Franks,K Hardy,SA Stubbs,J Stark,SM Dilworth,S Franks,K Hardy,

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Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of clinical endocrinology and metaboli

VOLUME: 92

Page Numbers: 4418-26

Journal Abbreviation: J. Clin. Endocrinol. Metab.

ISSN: 0021-972X

DAY: 14

MONTH: 08

YEAR: 2007

Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division. Information

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LANGUAGE: eng

NlmUniqueID: 375362

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AFFILIATION: Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom. k.hardy@imperial.ac.uk.

Country: United States

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MEDLINETA: J Clin Endocrinol Metab

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