Abnormal laminin secretion from parietal endoderm-like F9 cells in the presence of monensin.

Abnormal laminin secretion from parietal endoderm-like F9 cells in the presence of monensin. Research Abstract Details 

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Abnormal laminin secretion from parietal endoderm-like F9 cells in the presence of monensin. Abstract Text:

A Morita,Y Kitagawa,E Sugimoto,

We studied the effects of monensin on post-translational modification and intracellular transport of precursors of laminin subunits in parietal endoderm-like F9 cells. At concentrations higher than 0.1 microM, monensin inhibited the processing of high-mannose type precursors for all three subunits and caused their cytoplasmic accumulation. Furthermore, the secretion of mature subunits of laminin was inhibited. Instead, polypeptides with similar molecular weights to those of intracellular precursors were secreted. These polypeptides were immunologically related to laminin subunits and were sensitive to digestion with beta-N-acetylglucosaminidase H (Endo H). This indicated that Golgi complexes of the cells can transport the precursors of laminin subunits even with their terminal glycosylation inactivated by monensin. Tunicamycin induced the accumulation of unglycosylated precursors and strongly reduced their secretion into the medium.

Abnormal laminin secretion from parietal endoderm-like F9 cells in the presence of monensin. Publishing Authors By Initials

A Morita,Y Kitagawa,E Sugimoto,

For similar neoplasms: neoplasms by histologic type: neoplasms, germ cell and embryonal: teratoma research abstracts see: neoplasms: neoplasms by histologic type: neoplasms, germ cell and embryonal: teratoma research

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Abnormal laminin secretion from parietal endoderm-like F9 cells in the presence of monensin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 98

Page Numbers: 561-8

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Aug

YEAR: 1985

Abnormal laminin secretion from parietal endoderm-like F9 cells in the presence of monensin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Abnormal laminin secretion from parietal endoderm-like F9 cells in the presence of monensin. Keywords Mesh Terms:

KEYWORDS: Teratoma

MESH TERMS: secretion

Chemical & Substance for Abstract: Abnormal laminin secretion from parietal endoderm-like F9 cells in the presence of monensin. Information

Substance Name: Monensin

Registry Number: 17090-79-8

Grant and Affiliation Information for Abnormal laminin secretion from parietal endoderm-like F9 cells in the presence of monensin.

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Country: JAPAN

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MEDLINETA: J Biochem

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