Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene.

Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene. Research Abstract Details 

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Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene. Abstract Text:

C Wan,Y La,H Zhu,Y Yang,L Jiang,Y Chen,G Feng,H Li,H Sang,X Hao,G Zhang,L He,

In this study we focused on detecting schizophrenia related changes of plasma proteins using proteomic technology and examining the relation between schizophrenia and haptoglobin (Hp) genotype. We investigated plasma proteins from schizophrenic subjects (n = 42) and healthy controls (n = 46) by two-dimensional gel electrophoresis (2-DE) in combination with mass spectrometry. To further reveal the genetic relationship between acute phase proteins (APPs) and schizophrenia disease, we tested Hp alpha1/Hp alpha2 (Hp 1/2) polymorphism and two single nucleotide polymorphisms (SNPs) of Hp, rs2070937 and rs5473, for associations with schizophrenia in the Chinese Han population. With the relatively high number of samples for 2-DE work, we found that four proteins in the family of positive APPs were all up-regulated in patients. In genetic association study, we found significant associations existing between schizophrenia and Hp polymorphisms, Hp 1/2 and rs2070937 variants. Schizophrenia is accompanied by both an altered expression of Hp protein and a different genotype distribution of Hp gene, demonstrating that Hp is associated with schizophrenia. The results from proteomic and genomic aspects both indicate that acute phase reaction is likely to be an aetiological agent in the pathophysiology of schizophrenia, but not just an accompanying symptom. The positive APPs are schizophrenic related proteins, with the highly concordant results on four positive APPs.

Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene. Publishing Authors By Initials

C Wan,Y La,H Zhu,Y Yang,L Jiang,Y Chen,G Feng,H Li,H Sang,X Hao,G Zhang,L He,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Amino acids

VOLUME: 32

Page Numbers: 101-8

Journal Abbreviation: Amino Acids

ISSN: 0939-4451

DAY: 10

MONTH: 08

YEAR: 2006

Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene. Information

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LANGUAGE: eng

NlmUniqueID: 9200312

Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: genetics

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Substance Name: Proteome

Registry Number: 0

Grant and Affiliation Information for Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene.

AFFILIATION: Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China.

Country: Austria

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MEDLINETA: Amino Acids

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